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Tbio
SULF1
Extracellular sulfatase Sulf-1

Protein Summary
Description
Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation. This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260128
  • ENSP00000260128
  • ENSG00000137573
  • ENST00000402687
  • ENSP00000385704
  • ENST00000419716
  • ENSP00000390315
  • ENST00000458141
  • ENSP00000403040

Symbol
  • KIAA1077
  • SULF-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.99
transcription factor perturbation
0.94
gene perturbation
0.88
biological process
0.85
protein domain
0.85


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.3   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.3   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (94)
SDC2
Tbio
Novelty:  0.00597758
p_int:  0.999944592
p_ni:  0.000055169
p_wrong:  2.39e-7
Score:  0.439
Data Source:  BioPlex,STRINGDB
APP
Tchem
Novelty:  0.00008964
p_int:  0.999910216
p_ni:  0.000089672
p_wrong:  1.11e-7
Score:  0.185
Data Source:  BioPlex,STRINGDB
LRRC4C
Tbio
Novelty:  0.06534005
p_int:  0.99922993
p_ni:  0.000357045
p_wrong:  0.000413026
Score:  0.157
Data Source:  BioPlex,STRINGDB
OS9
Tbio
Novelty:  0.01490339
p_int:  0.998629041
p_ni:  0.001363618
p_wrong:  0.000007342
Data Source:  BioPlex
LYZL2
Tdark
Family:  Enzyme
Novelty:  0.50542161
p_int:  0.998016449
p_ni:  0.001506995
p_wrong:  0.000476556
Data Source:  BioPlex
NOG
Tbio
Novelty:  0.0010373
p_int:  0.993461755
p_ni:  0.006353829
p_wrong:  0.000184415
Score:  0.302
Data Source:  BioPlex,STRINGDB
INSL5
Tbio
Novelty:  0.04351334
p_int:  0.988543146
p_ni:  0.00656494
p_wrong:  0.004891914
Data Source:  BioPlex
INS
Tbio
Novelty:  0.00000499
p_int:  0.76467636
p_ni:  0.02880342
p_wrong:  0.20652022
Score:  0.189
Data Source:  BioPlex,STRINGDB
SLCO5A1
Tbio
Family:  Transporter
Novelty:  0.17025746
Score:  0.908
Data Source:  STRINGDB
ARSH
Tbio
Family:  Enzyme
Novelty:  0.03202479
Score:  0.858
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
1
1
1
17.3
FEV/FEC ratio
1
1
1
9.5
thyroid stimulating hormone measurement
1
1
1
5.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
1
17.3
FEV/FEC ratio
1
9.5
thyroid stimulating hormone measurement
1
5.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sulfatase 1
VGNC:14596
472787
Macaque
sulfatase 1
705606
Mouse
MGI:2138563
240725
Rat
RGD:708554
171396
Dog
sulfatase 1
VGNC:46974
486986
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sulfatase 1
Macaque
sulfatase 1
Mouse
Rat
Dog
sulfatase 1
Publication Statistics
PubMed Score 130.30
PubMed score by year
PubTator Score 72.19
PubTator score by year
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Related Publications
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PMID
Year
Title