Tbio SULF1 Extracellular sulfatase Sulf-1

Protein Summary

Description

Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation. This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• Q8IWU6
• Q86YV8
• Q8NCA2
• Q9UPS5
• hSulf-1

Gene Name

• SULF1

Ensembl ID

• ENST00000260128
• ENSP00000260128
• ENSG00000137573
• ENST00000402687
• ENSP00000385704
• ENST00000419716
• ENSP00000390315
• ENST00000458141
• ENSP00000403040

Symbol

• KIAA1077
• SULF-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.99
transcription factor perturbation	0.94
gene perturbation	0.88
biological process	0.85
protein domain	0.85

Protein Classes

PANTHER Classes

Protein / Hydrolase / Extracellular Sulfatase Sulf-1

DTO Classes

Protein / Enzyme / Hydrolase / Extracellular Sulfatase Sulf-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.3   (req: < 5)

Gene RIFs: 51   (req: <= 3)

Antibodies: 108   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.3   (req: >= 5)

Gene RIFs: 51   (req: > 3)

Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (94)

Explore Interacting Targets

1 – 10 of 94

• See Interactions on String-DB

SDC2

Tbio

Novelty:  0.00597758

p_int:  0.999944592

p_ni:  0.000055169

p_wrong:  2.39e-7

Score:  0.439

Data Source:  BioPlex,STRINGDB

APP

Tchem

Novelty:  0.00008964

p_int:  0.999910216

p_ni:  0.000089672

p_wrong:  1.11e-7

Score:  0.185

Data Source:  BioPlex,STRINGDB

LRRC4C

Tbio

Novelty:  0.06534005

p_int:  0.99922993

p_ni:  0.000357045

p_wrong:  0.000413026

Score:  0.157

Data Source:  BioPlex,STRINGDB

OS9

Tbio

Novelty:  0.01490339

p_int:  0.998629041

p_ni:  0.001363618

p_wrong:  0.000007342

Data Source:  BioPlex

LYZL2

Tdark

Family:  Enzyme

Novelty:  0.50542161

p_int:  0.998016449

p_ni:  0.001506995

p_wrong:  0.000476556

Data Source:  BioPlex

NOG

Tbio

Novelty:  0.0010373

p_int:  0.993461755

p_ni:  0.006353829

p_wrong:  0.000184415

Score:  0.302

Data Source:  BioPlex,STRINGDB

INSL5

Tbio

Novelty:  0.04351334

p_int:  0.988543146

p_ni:  0.00656494

p_wrong:  0.004891914

Data Source:  BioPlex

INS

Tbio

Novelty:  0.00000499

p_int:  0.76467636

p_ni:  0.02880342

p_wrong:  0.20652022

Score:  0.189

Data Source:  BioPlex,STRINGDB

SLCO5A1

Tbio

Family:  Transporter

Novelty:  0.17025746

Score:  0.908

Data Source:  STRINGDB

ARSH

Tbio

Family:  Enzyme

Novelty:  0.03202479

Score:  0.858

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (33)

Functions (4)

Components (7)

Processes (22)

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1 – 4 of 4

GO Term	Evidence	Assigned by
arylsulfatase activity	Inferred from Direct Assay (IDA)	UniProtKB
N-acetylglucosamine-6-sulfatase activity	Inferred from Direct Assay (IDA)	UniProtKB
glycosaminoglycan binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
calcium ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (3)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
forced expiratory volume	EFO_0004314	1	1	1		17.3
FEV/FEC ratio	EFO_0004713	1	1	1		9.5
thyroid stimulating hormone measurement	EFO_0004748	1	1	1		5.2

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5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
forced expiratory volume	EFO_0004314	1		17.3
FEV/FEC ratio	EFO_0004713	1		9.5
thyroid stimulating hormone measurement	EFO_0004748	1		5.2

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UniProt Keyword Find Similar Targets

No Header	No Header
Apoptosis
Calcium
Complete proteome
Endoplasmic reticulum
Glycoprotein
Golgi apparatus
Hydrolase
Metal-binding
Reference proteome
Signal

GWAS Trait Find Similar Targets

No Header	No Header
FEV/FEC ratio
forced expiratory volume
thyroid stimulating hormone measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
immune system phenotype
mortality/aging
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	sulfatase 1	VGNC:14596	472787
Macaque	sulfatase 1		705606
Mouse	sulfatase 1	MGI:2138563	240725
Rat	sulfatase 1	RGD:708554	171396
Dog	sulfatase 1	VGNC:46974	486986

Species	Name	OMA	EggNOG	Inparanoid
Chimp	sulfatase 1
Macaque	sulfatase 1
Mouse	sulfatase 1
Rat	sulfatase 1
Dog	sulfatase 1

Publication Statistics

PubMed Score 130.30

PubMed score by year

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PubTator Score 72.19

PubTator score by year

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Related Publications

Text Mined References (107)

GeneRif Annotations (51)

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PMID	Year	Title