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Tbio
SULF1
Extracellular sulfatase Sulf-1

Protein Classes
Protein Summary
Description
Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation. This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260128
  • ENSP00000260128
  • ENSG00000137573
  • ENST00000402687
  • ENSP00000385704
  • ENST00000419716
  • ENSP00000390315
  • ENST00000458141
  • ENSP00000403040

Symbol
  • KIAA1077
  • SULF-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.99
transcription factor perturbation
0.94
gene perturbation
0.88
biological process
0.85
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.36   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.36   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (94)
1 – 10 of 94
SDC2
Tbio
Novelty: 0.00597758
p_int: 0.999944592
p_ni: 0.000055169
p_wrong: 2.39e-7
Score: 0.439
Data Source: BioPlex,STRINGDB
APP
Tchem
Novelty: 0.00008964
p_int: 0.999910216
p_ni: 0.000089672
p_wrong: 1.11e-7
Score: 0.185
Data Source: BioPlex,STRINGDB
LRRC4C
Tbio
Novelty: 0.06534005
p_int: 0.99922993
p_ni: 0.000357045
p_wrong: 0.000413026
Score: 0.157
Data Source: BioPlex,STRINGDB
OS9
Tbio
Novelty: 0.01490339
p_int: 0.998629041
p_ni: 0.001363618
p_wrong: 0.000007342
Data Source: BioPlex
LYZL2
Tdark
Family: Enzyme
Novelty: 0.50542161
p_int: 0.998016449
p_ni: 0.001506995
p_wrong: 0.000476556
Data Source: BioPlex
NOG
Tbio
Novelty: 0.0010373
p_int: 0.993461755
p_ni: 0.006353829
p_wrong: 0.000184415
Score: 0.302
Data Source: BioPlex,STRINGDB
INSL5
Tbio
Novelty: 0.04351334
p_int: 0.988543146
p_ni: 0.00656494
p_wrong: 0.004891914
Data Source: BioPlex
INS
Tbio
Novelty: 0.00000499
p_int: 0.76467636
p_ni: 0.02880342
p_wrong: 0.20652022
Score: 0.189
Data Source: BioPlex,STRINGDB
SLCO5A1
Tbio
Family: Transporter
Novelty: 0.17025746
Score: 0.908
Data Source: STRINGDB
ARSH
Tbio
Family: Enzyme
Novelty: 0.03202479
Score: 0.858
Data Source: STRINGDB
Publication Statistics
PubMed Score  124.36

PubMed score by year
PubTator Score  72.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer