You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SULF2
Extracellular sulfatase Sulf-2

Protein Classes
Protein Summary
Description
Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359930
  • ENSP00000353007
  • ENSG00000196562
  • ENST00000467815
  • ENSP00000418442
  • ENST00000484875
  • ENSP00000418290

Symbol
  • KIAA1247
  • HSULF-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
PubMedID
0.93
small molecule perturbation
0.9
protein domain
0.85
kinase perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.72   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 310   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.72   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (94)
1 – 10 of 94
RARRES1
Tbio
Family: Enzyme
Novelty: 0.03698309
p_int: 0.999781822
p_ni: 0.000218178
Data Source: BioPlex
SPON1
Tbio
Novelty: 0.00388947
p_int: 0.999450809
p_ni: 0.00054919
p_wrong: 1e-9
Data Source: BioPlex
CSGALNACT2
Tbio
Family: Enzyme
Novelty: 0.1003811
p_int: 0.999300737
p_ni: 0.000697137
p_wrong: 0.000002126
Score: 0.465
Data Source: BioPlex,STRINGDB
APP
Tchem
Novelty: 0.00011446
p_int: 0.999091512
p_ni: 0.000908488
Score: 0.168
Data Source: BioPlex,STRINGDB
LRRC4C
Tbio
Novelty: 0.00535393
p_int: 0.999021346
p_ni: 0.000978646
p_wrong: 8e-9
Data Source: BioPlex
DEFA1
Tbio
Novelty: 0.01616437
p_int: 0.998406151
p_ni: 0.001593848
p_wrong: 1e-9
Data Source: BioPlex
GPR156
Tdark
Family: GPCR
Novelty: 0.46666667
p_int: 0.998023667
p_ni: 0.001976332
p_wrong: 2e-9
Data Source: BioPlex
OS9
Tbio
Novelty: 0.01598375
p_int: 0.997699108
p_ni: 0.002300852
p_wrong: 4.1e-8
Data Source: BioPlex
KBTBD7
Tdark
Novelty: 1.01449275
p_int: 0.995941573
p_ni: 0.00388117
p_wrong: 0.000177257
Data Source: BioPlex
CASQ2
Tbio
Novelty: 0.01062563
p_int: 0.994792937
p_ni: 0.005204492
p_wrong: 0.000002571
Data Source: BioPlex
Publication Statistics
PubMed Score  75.72

PubMed score by year
PubTator Score  69.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: