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Tbio
SULF2
Extracellular sulfatase Sulf-2

Protein Classes
Protein Summary
Description
Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359930
  • ENSP00000353007
  • ENSG00000196562
  • ENST00000467815
  • ENSP00000418442
  • ENST00000484875
  • ENSP00000418290

Symbol
  • KIAA1247
  • HSULF-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
PubMedID
0.93
small molecule perturbation
0.9
protein domain
0.85
kinase perturbation
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.19   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 310   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.19   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
3
6
7
94.2
apolipoprotein A 1 measurement
2
5
5
93.2
balding measurement
1
1
1
49.5
snoring measurement
1
1
0
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
7
94.2
apolipoprotein A 1 measurement
5
93.2
balding measurement
1
49.5
snoring measurement
0
1
24.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
sulfatase 2
715937
Mouse
MGI:1919293
72043
Rat
RGD:1305078
311642
Dog
sulfatase 2
VGNC:46975
477254
Horse
sulfatase 2
VGNC:23754
100056840
Species
Name
OMA
EggNOG
Inparanoid
Macaque
sulfatase 2
Mouse
Rat
Dog
sulfatase 2
Horse
sulfatase 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IWU5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (94)
1 – 10 of 94
RARRES1
Tbio
Family:  Enzyme
Novelty:  0.04701793
p_int:  0.999781822
p_ni:  0.000218178
Data Source:  BioPlex
SPON1
Tbio
Novelty:  0.01071398
p_int:  0.999450809
p_ni:  0.00054919
p_wrong:  1e-9
Data Source:  BioPlex
CSGALNACT2
Tbio
Family:  Enzyme
Novelty:  0.0770692
p_int:  0.999300737
p_ni:  0.000697137
p_wrong:  0.000002126
Score:  0.465
Data Source:  BioPlex,STRINGDB
APP
Tchem
Novelty:  0.00008964
p_int:  0.999091512
p_ni:  0.000908488
Score:  0.168
Data Source:  BioPlex,STRINGDB
LRRC4C
Tbio
Novelty:  0.06534005
p_int:  0.999021346
p_ni:  0.000978646
p_wrong:  8e-9
Data Source:  BioPlex
DEFA1
Tbio
Novelty:  0.01027492
p_int:  0.998406151
p_ni:  0.001593848
p_wrong:  1e-9
Data Source:  BioPlex
GPR156
Tdark
Family:  GPCR
Novelty:  0.39183023
p_int:  0.998023667
p_ni:  0.001976332
p_wrong:  2e-9
Data Source:  BioPlex
OS9
Tbio
Novelty:  0.01490339
p_int:  0.997699108
p_ni:  0.002300852
p_wrong:  4.1e-8
Data Source:  BioPlex
KBTBD7
Tdark
Novelty:  0.4947466
p_int:  0.995941573
p_ni:  0.00388117
p_wrong:  0.000177257
Data Source:  BioPlex
CASQ2
Tbio
Novelty:  0.00775794
p_int:  0.994792937
p_ni:  0.005204492
p_wrong:  0.000002571
Data Source:  BioPlex
Publication Statistics
PubMed Score  98.19

PubMed score by year
PubTator Score  69.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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