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Tbio
SLC30A8
Zinc transporter 8

Protein Summary
Description
Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells. The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000427715
  • ENSP00000407505
  • ENSG00000164756
  • ENST00000456015
  • ENSP00000415011
  • ENST00000519688
  • ENSP00000431069
  • ENST00000521243
  • ENSP00000428545

Symbol
  • ZNT8
  • ZNT8
  • ZnT-8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
cell type or tissue
0.9
microRNA
0.89
biological process
0.8
biological term
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 273.58   (req: < 5)
Gene RIFs: 121   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 273.58   (req: >= 5)
Gene RIFs: 121   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (133)
PTPRN
Tbio
Family:  Enzyme
Novelty:  0.00076479
Score:  0.892
Data Source:  STRINGDB
CDKAL1
Tbio
Family:  Enzyme
Novelty:  0.01013607
Score:  0.862
Data Source:  STRINGDB
IGF2BP2
Tbio
Novelty:  0.0105554
Score:  0.836
Data Source:  STRINGDB
TCF7L2
Tbio
Family:  TF
Novelty:  0.00178694
Score:  0.831
Data Source:  STRINGDB
G6PC2
Tbio
Family:  Enzyme
Novelty:  0.01361918
Score:  0.801
Data Source:  STRINGDB
GAD2
Tbio
Family:  Enzyme
Novelty:  0.00058427
Score:  0.79
Data Source:  STRINGDB
HHEX
Tbio
Family:  TF
Novelty:  0.00548107
Score:  0.789
Data Source:  STRINGDB
SLC30A6
Tbio
Family:  Transporter
Novelty:  0.06083299
Score:  0.779
Data Source:  STRINGDB
KCNJ11
Tclin
Family:  IC
Novelty:  0.00068183
Score:  0.765
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.764
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Insulin processing (R-HSA-264876)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Insulin processing
Reactome
Metabolism of proteins
Reactome
Metal ion SLC transporters
Reactome
Peptide hormone metabolism
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Insulin processing
Metabolism of proteins
Metal ion SLC transporters
Peptide hormone metabolism
SLC-mediated transmembrane transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
25
6
6
1.1
99.2
HbA1c measurement
7
5
8
92.3
fasting blood glucose measurement
8
2
8
91
glucose measurement
4
3
4
84.5
body mass index
2
2
2
84.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
1.1
99.2
HbA1c measurement
8
92.3
fasting blood glucose measurement
8
91
glucose measurement
4
84.5
body mass index
2
84.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 30 member 8
VGNC:14608
464348
Mouse
MGI:2442682
239436
Rat
RGD:1308282
299903
Dog
solute carrier family 30 member 8
VGNC:46353
482022
Horse
solute carrier family 30 member 8
VGNC:23153
100056898
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 30 member 8
Mouse
Rat
Dog
solute carrier family 30 member 8
Horse
solute carrier family 30 member 8
Publication Statistics
PubMed Score 273.58
PubMed score by year
PubTator Score 269.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title