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Tbio
LMTK2
Serine/threonine-protein kinase LMTK2

Protein Summary
Description
Phosphorylates PPP1C, phosphorylase b and CFTR. The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297293
  • ENSP00000297293
  • ENSG00000164715

Symbol
  • AATYK2
  • BREK
  • KIAA1079
  • KPI2
  • LMR2
  • BREK
  • KPI2
  • LMR2
  • cprk
  • KPI-2
  • hBREK
  • AATYK2
  • PPP1R100
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
kinase perturbation
0.81
transcription factor binding site profile
0.78
trait
0.75
protein domain
0.73


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.98   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.98   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
3
2
0
1.1
97.1
neuroticism measurement
1
1
0
5.5
48.2
1
1
0
1.1
36.8
serum gamma-glutamyl transferase measurement
1
1
1
29.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
0
1.1
97.1
neuroticism measurement
0
5.5
48.2
0
1.1
36.8
serum gamma-glutamyl transferase measurement
1
29.9
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lemur tyrosine kinase 2
VGNC:4416
472454
Macaque
lemur tyrosine kinase 2
718147
Mouse
MGI:3036247
231876
Rat
RGD:1598332
304286
Dog
lemur tyrosine kinase 2
VGNC:42727
608946
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lemur tyrosine kinase 2
Macaque
lemur tyrosine kinase 2
Mouse
Rat
Dog
lemur tyrosine kinase 2
Gene Ontology Terms (29)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (31)
1 – 10 of 31
PPP1CC
Tchem
Family: Enzyme
Novelty: 0.00465946
p_int: 0.999999967
p_ni: 2e-9
p_wrong: 3.1e-8
Score: 0.743
Data Source: BioPlex,STRINGDB
SLC34A2
Tbio
Family: Transporter
Novelty: 0.00601743
p_int: 0.993978166
p_ni: 0.000029314
p_wrong: 0.00599252
Score: 0.319
Data Source: BioPlex,STRINGDB
PPP1CA
Tchem
Family: Enzyme
Novelty: 0.00354658
Score: 0.912
Data Source: STRINGDB
PPP1CB
Tbio
Family: Enzyme
Novelty: 0.0122614
Score: 0.865
Data Source: STRINGDB
CDK5
Tchem
Family: Kinase
Novelty: 0.00071394
Score: 0.757
Data Source: STRINGDB
LARGE2
Tbio
Family: Enzyme
Novelty: 0.11843777
Score: 0.715
Data Source: STRINGDB
PPP1R2
Tbio
Family: Enzyme
Novelty: 0.02581522
Score: 0.703
Data Source: STRINGDB
CFTR
Tclin
Family: IC
Novelty: 0.00012639
Score: 0.659
Data Source: STRINGDB
CPNE3
Tbio
Novelty: 0.06125038
Score: 0.609
Data Source: STRINGDB
MSMB
Tbio
Novelty: 0.00241546
Score: 0.589
Data Source: STRINGDB
Publication Statistics
PubMed Score  56.98

PubMed score by year
PubTator Score  22.87

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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