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Tbio
CUL9
Cullin-9

Protein Summary
Description
Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252050
  • ENSP00000252050
  • ENSG00000112659

Symbol
  • H7AP1
  • KIAA0708
  • PARC
  • PARC
  • H7AP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.91
tissue sample
0.66
small molecule perturbation
0.63
transcription factor perturbation
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.12   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.12   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
TP53
Tchem
Family:  TF
Novelty:  0.00001907
p_int:  0.999999972
p_ni:  1.7e-8
p_wrong:  1.1e-8
Score:  0.681
Data Source:  BioPlex,STRINGDB
GLMN
Tbio
Novelty:  0.01940401
p_int:  0.999999694
p_ni:  3.05e-7
Score:  0.485
Data Source:  BioPlex,STRINGDB
APEX2
Tbio
Family:  Enzyme
Novelty:  0.04076395
p_int:  0.999989158
p_ni:  0.000010841
p_wrong:  1e-9
Score:  0.208
Data Source:  BioPlex,STRINGDB
ZKSCAN8
Tbio
Family:  TF
Novelty:  0.17881042
p_int:  0.999987273
p_ni:  0.000012727
Data Source:  BioPlex
RAB6B
Tbio
Family:  Enzyme
Novelty:  0.0865097
p_int:  0.999855453
p_ni:  0.000144401
p_wrong:  1.46e-7
Score:  0.161
Data Source:  BioPlex,STRINGDB
FEZF1
Tbio
Family:  TF
Novelty:  0.01942826
p_int:  0.999029053
p_ni:  0.000970947
Data Source:  BioPlex
TTC9C
Tdark
Novelty:  0.85949913
p_int:  0.950755196
p_ni:  0.000764859
p_wrong:  0.048479945
Data Source:  BioPlex
RBX1
Tbio
Family:  Enzyme
Novelty:  0.00596986
Score:  0.978
Data Source:  Reactome,STRINGDB
CUL7
Tbio
Novelty:  0.02183958
Score:  0.956
Data Source:  Reactome,STRINGDB
NEDD8
Tchem
Novelty:  0.00305343
Score:  0.956
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age-related hearing impairment
2
2
1
8.8
85.3
glomerular filtration rate
3
2
3
85
testosterone measurement
2
2
2
79.4
urate measurement
2
2
3
72.8
hemoglobin measurement
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age-related hearing impairment
1
8.8
85.3
glomerular filtration rate
3
85
testosterone measurement
2
79.4
urate measurement
3
72.8
hemoglobin measurement
1
58.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cullin 9
VGNC:2680
463192
Macaque
cullin 9
698984
Mouse
MGI:1925559
78309
Rat
RGD:1562008
316228
Dog
cullin 9
VGNC:39735
481809
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cullin 9
Macaque
cullin 9
Mouse
Rat
Dog
cullin 9
Publication Statistics
PubMed Score 10.12
PubMed score by year
PubTator Score 282.91
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title