SCN4B
Sodium channel subunit beta-4
Protein Summary
Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom. The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009]
- ENST00000324727
- ENSP00000322460
- ENSG00000177098
- ENST00000529878
- ENSP00000436343
- LQT10
- ATFB17
- Navbeta4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.98 | ||
molecular function | 0.91 | ||
protein domain | 0.73 | ||
histone modification site profile | 0.64 | ||
PubMedID | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 47.48 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 118 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 47.48 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 118 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (90)
Nearest Tclin Targets (3)
Upstream (3)
1 – 3 of 3
Pathways (55)
Reactome (7)
KEGG (1)
WikiPathways (47)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Cardiac conduction | ||||
Reactome | Developmental Biology | ||||
Reactome | Interaction between L1 and Ankyrins | ||||
Reactome | L1CAM interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Cardiac conduction | ||||
Developmental Biology | ||||
Interaction between L1 and Ankyrins | ||||
L1CAM interactions | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (5)
Components (3)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
neutrophil count | 4 | 3 | 6 | 86.7 | |||||
leukocyte count | 3 | 2 | 4 | 82 | |||||
myeloid white cell count | 2 | 1 | 2 | 74.5 | |||||
sleep duration | 1 | 1 | 0 | 1.2 | 73.8 | ||||
1 | 1 | 0 | 1.1 | 68.6 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
neutrophil count | 6 | 86.7 | |||||
leukocyte count | 4 | 82 | |||||
myeloid white cell count | 2 | 74.5 | |||||
sleep duration | 0 | 1.2 | 73.8 | ||||
0 | 1.1 | 68.6 | |||||
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IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | sodium voltage-gated channel beta subunit 4 | VGNC:11660 | 742047 | |||||
Mouse | MGI:2687406 | 399548 | ||||||
Rat | RGD:631404 | 315611 | ||||||
Dog | sodium voltage-gated channel beta subunit 4 | VGNC:53439 | 100688178 | |||||
Horse | sodium voltage-gated channel beta subunit 4 | VGNC:22739 | 100071197 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | sodium voltage-gated channel beta subunit 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | sodium voltage-gated channel beta subunit 4 | |||||
Horse | sodium voltage-gated channel beta subunit 4 | |||||
Publication Statistics
PubMed Score 47.48
PubMed score by year
PubTator Score 13.09
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (23)
GeneRif Annotations (18)
Items per page:
0 of 0
PMID | Year | Title |
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