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Tbio
SCN4B
Sodium channel subunit beta-4

Protein Summary
Description
Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom. The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324727
  • ENSP00000322460
  • ENSG00000177098
  • ENST00000529878
  • ENSP00000436343

Symbol
  • LQT10
  • ATFB17
  • Navbeta4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
molecular function
0.91
protein domain
0.73
histone modification site profile
0.64
PubMedID
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.48   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.48   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (90)
SCN5A
Tclin
Family:  IC
Novelty:  0.00050944
Score:  0.977
Data Source:  STRINGDB
ANK2
Tbio
Novelty:  0.00528351
Score:  0.973
Data Source:  STRINGDB
SCN2A
Tclin
Family:  IC
Novelty:  0.0007317
Score:  0.971
Data Source:  STRINGDB
SCN1B
Tbio
Family:  IC
Novelty:  0.00910273
Score:  0.97
Data Source:  STRINGDB
SCN1A
Tclin
Family:  IC
Novelty:  0.00109424
Score:  0.966
Data Source:  STRINGDB
SCN8A
Tclin
Family:  IC
Novelty:  0.00203805
Score:  0.966
Data Source:  STRINGDB
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
Score:  0.966
Data Source:  STRINGDB
SCN9A
Tclin
Family:  IC
Novelty:  0.00169067
Score:  0.958
Data Source:  STRINGDB
SCN4A
Tclin
Family:  IC
Novelty:  0.00185911
Score:  0.958
Data Source:  STRINGDB
SCN3A
Tclin
Family:  IC
Novelty:  0.00646122
Score:  0.957
Data Source:  STRINGDB
Pathways (55)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cardiac conduction
Reactome
Developmental Biology
Reactome
Interaction between L1 and Ankyrins
Reactome
L1CAM interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Cardiac conduction
Developmental Biology
Interaction between L1 and Ankyrins
L1CAM interactions
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
4
3
6
86.7
leukocyte count
3
2
4
82
myeloid white cell count
2
1
2
74.5
sleep duration
1
1
0
1.2
73.8
1
1
0
1.1
68.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
6
86.7
leukocyte count
4
82
myeloid white cell count
2
74.5
sleep duration
0
1.2
73.8
0
1.1
68.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sodium voltage-gated channel beta subunit 4
VGNC:11660
742047
Mouse
MGI:2687406
399548
Rat
RGD:631404
315611
Dog
sodium voltage-gated channel beta subunit 4
VGNC:53439
100688178
Horse
sodium voltage-gated channel beta subunit 4
VGNC:22739
100071197
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sodium voltage-gated channel beta subunit 4
Mouse
Rat
Dog
sodium voltage-gated channel beta subunit 4
Horse
sodium voltage-gated channel beta subunit 4
Publication Statistics
PubMed Score 47.48
PubMed score by year
PubTator Score 13.09
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title