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Tbio
SCN4B
Sodium channel subunit beta-4

Protein Summary
Description
Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom. The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324727
  • ENSP00000322460
  • ENSG00000177098
  • ENST00000529878
  • ENSP00000436343

Symbol
  • LQT10
  • ATFB17
  • Navbeta4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
molecular function
0.91
protein domain
0.73
histone modification site profile
0.64
PubMedID
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.77   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.77   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (55)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cardiac conduction
Reactome
Developmental Biology
Reactome
Interaction between L1 and Ankyrins
Reactome
L1CAM interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Cardiac conduction
Developmental Biology
Interaction between L1 and Ankyrins
L1CAM interactions
Gene Ontology Terms (18)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (90)
1 – 10 of 90
SCN5A
Tclin
Family: IC
Novelty: 0.00050944
Score: 0.977
Data Source: STRINGDB
ANK2
Tbio
Novelty: 0.00528351
Score: 0.973
Data Source: STRINGDB
SCN2A
Tclin
Family: IC
Novelty: 0.0007317
Score: 0.971
Data Source: STRINGDB
SCN1B
Tbio
Family: IC
Novelty: 0.00910273
Score: 0.97
Data Source: STRINGDB
SCN1A
Tclin
Family: IC
Novelty: 0.00109424
Score: 0.966
Data Source: STRINGDB
SCN8A
Tclin
Family: IC
Novelty: 0.00203805
Score: 0.966
Data Source: STRINGDB
SCN3B
Tbio
Family: IC
Novelty: 0.0438123
Score: 0.966
Data Source: STRINGDB
SCN9A
Tclin
Family: IC
Novelty: 0.00169067
Score: 0.958
Data Source: STRINGDB
SCN4A
Tclin
Family: IC
Novelty: 0.00185911
Score: 0.958
Data Source: STRINGDB
SCN3A
Tclin
Family: IC
Novelty: 0.00646122
Score: 0.957
Data Source: STRINGDB
Publication Statistics
PubMed Score  39.77

PubMed score by year
PubTator Score  13.09

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer