Tbio SCN4B Sodium channel subunit beta-4

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Voltage-gated Ion Channel / Voltage-gated Sodium Channel / Sodium Channel Subunit Beta-4

Protein / Transporter / Ion Channel / Sodium Channel / Voltage-gated Sodium Channel / Sodium Channel Subunit Beta-4

Protein / Cell Adhesion Molecule / Sodium Channel Subunit Beta-4

DTO Classes

Protein / Ion Channel / Sodium Channel Auxiliary Subunit 1-4 (Sca-) Family / Scn4b Family / Sodium Channel Subunit Beta-4

Protein Summary

Description

Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom. The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• Q8IWT1
• E9PPT5
• Q6PIG5

Gene Name

• SCN4B

Ensembl ID

• ENST00000324727
• ENSP00000322460
• ENSG00000177098
• ENST00000529878
• ENSP00000436343

Symbol

• LQT10
• ATFB17
• Navbeta4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.98
molecular function	0.91
protein domain	0.73
histone modification site profile	0.64
PubMedID	0.57

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.77   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 118   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.77   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (3)

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (55)

Reactome (7)

KEGG (1)

WikiPathways (47)

Axon guidance (R-HSA-422475)

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5

1 – 5 of 7

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Cardiac conduction	137 targets	R-HSA-5576891
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Interaction between L1 and Ankyrins	29 targets	R-HSA-445095
Reactome	L1CAM interactions	100 targets	R-HSA-373760

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Cardiac conduction	137 targets	R-HSA-5576891
Developmental Biology	1055 targets	R-HSA-1266738
Interaction between L1 and Ankyrins	29 targets	R-HSA-445095
L1CAM interactions	100 targets	R-HSA-373760

Gene Ontology Terms (18)

Functions (5)

Components (3)

Processes (10)

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Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
sodium channel regulator activity	Inferred from Direct Assay (IDA)	UniProtKB
voltage-gated sodium channel activity	Inferred from Direct Assay (IDA)	UniProtKB
ion channel binding	Inferred from Physical Interaction (IPI)	BHF-UCL
voltage-gated sodium channel activity involved in cardiac muscle cell action potential	Inferred from Mutant Phenotype (IMP)	BHF-UCL
voltage-gated ion channel activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (90)

Explore Interacting Targets

1 – 10 of 90

• See Interactions on String-DB

SCN5A

Tclin

Family: IC

Novelty: 0.00050944

Score: 0.977

Data Source: STRINGDB

ANK2

Tbio

Novelty: 0.00528351

Score: 0.973

Data Source: STRINGDB

SCN2A

Tclin

Family: IC

Novelty: 0.0007317

Score: 0.971

Data Source: STRINGDB

SCN1B

Tbio

Family: IC

Novelty: 0.00910273

Score: 0.97

Data Source: STRINGDB

SCN1A

Tclin

Family: IC

Novelty: 0.00109424

Score: 0.966

Data Source: STRINGDB

SCN8A

Tclin

Family: IC

Novelty: 0.00203805

Score: 0.966

Data Source: STRINGDB

SCN3B

Tbio

Family: IC

Novelty: 0.0438123

Score: 0.966

Data Source: STRINGDB

SCN9A

Tclin

Family: IC

Novelty: 0.00169067

Score: 0.958

Data Source: STRINGDB

SCN4A

Tclin

Family: IC

Novelty: 0.00185911

Score: 0.958

Data Source: STRINGDB

SCN3A

Tclin

Family: IC

Novelty: 0.00646122

Score: 0.957

Data Source: STRINGDB

Publication Statistics

PubMed Score  39.77

PubMed score by year

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PubTator Score  13.09

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Alternative splicing
Atrial fibrillation
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Immunoglobulin domain
Ion channel

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
nervous system phenotype