Tbio ZBTB8OS Protein archease

Protein Summary

Description

Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB. Together with DDX1, acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation.

Uniprot Accession IDs

• Q8IWT0
• Q5TGK5
• Q6PDA1
• Q8IWS9
• Q8NEV6
• Q8NEV7

Gene Name

• ZBTB8OS

Ensembl ID

• ENST00000373501
• ENSP00000362600
• ENSG00000176261

Symbol

• ARCH
• ARCH
• ARCH2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.84
transcription factor binding site profile	0.82
histone modification site profile	0.69
cell type or tissue	0.61
tissue sample	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.63   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 48   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.63   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0