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Tchem
BRSK2
Serine/threonine-protein kinase BRSK2

Protein Summary
Description
Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945) ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308219
  • ENSP00000310697
  • ENSG00000174672
  • ENST00000382179
  • ENSP00000371614
  • ENST00000526678
  • ENSP00000433370
  • ENST00000528710
  • ENSP00000433235
  • ENST00000528841
  • ENSP00000432000
  • ENST00000529433
  • ENSP00000433684
  • ENST00000531197
  • ENSP00000431152

Symbol
  • C11orf7
  • PEN11B
  • SADA
  • STK29
  • SAD1
  • SADA
  • STK29
  • PEN11B
  • C11orf7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
protein domain
0.73
tissue sample
0.71
transcription factor
0.71
biological process
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.16   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.16   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
1
0
7
76.6
mathematical ability
1
1
1
54.7
chronotype measurement
1
1
1
53.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
0
7
76.6
mathematical ability
1
54.7
chronotype measurement
1
53.4
Gene Ontology Terms (32)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Non-traceable Author Statement (NAS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (61)
1 – 10 of 61
CAB39
Tbio
Novelty: 0.01592402
Score: 0.951
Data Source: STRINGDB
MAPT
Tchem
Novelty: 0.00013232
Score: 0.942
Data Source: STRINGDB
STK11
Tchem
Family: Kinase
Novelty: 0.00073247
Score: 0.935
Data Source: STRINGDB
STRADA
Tbio
Family: Kinase
Novelty: 0.0190243
Score: 0.928
Data Source: STRINGDB
MAP2
Tchem
Novelty: 0.00068493
Score: 0.921
Data Source: STRINGDB
STRADB
Tbio
Family: Kinase
Novelty: 0.03532206
Score: 0.902
Data Source: STRINGDB
CDC25B
Tchem
Family: Enzyme
Novelty: 0.00378458
Score: 0.786
Data Source: STRINGDB
CDC25C
Tchem
Family: Enzyme
Novelty: 0.00227769
Score: 0.743
Data Source: STRINGDB
WEE1
Tchem
Family: Kinase
Novelty: 0.00162432
Score: 0.676
Data Source: STRINGDB
FZR1
Tbio
Novelty: 0.01599606
Score: 0.672
Data Source: STRINGDB
Publication Statistics
PubMed Score  71.16

PubMed score by year
PubTator Score  60.73

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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