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Tbio
RP1L1
Retinitis pigmentosa 1-like 1 protein

Protein Summary
Description
Required for the differentiation of photoreceptor cells. Plays a role in the organization of outer segment of rod and cone photoreceptors (By similarity). This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, and two C-terminal large repetitive regions, both of which contain a high percentage of glutamine and glutamic acid residues. This protein is a retinal-specific protein. Its exact length varies among individuals due to the presence of a 16aa repeat in the first C-terminal repetitive region. The 16aa repeat is encoded by the highly polymorphic 48-bp repeat, and 1-6 copies of the 16aa repeat have been identified in normal individuals. The current reference sequence shown here has a single copy of the 16aa repeat. This protein and the RP1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382483
  • ENSP00000371923
  • ENSG00000183638

Symbol
  • DCDC4B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.78
cell type or tissue
0.74
tissue sample
0.69
cell line
0.63
cellular component
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.99   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.99   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
2
4
5
95.7
appendicular lean mass
1
1
1
76.8
triglyceride measurement
2
2
3
72.9
mean corpuscular hemoglobin concentration
1
1
1
66.9
mathematical ability
1
1
1
66.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
5
95.7
appendicular lean mass
1
76.8
triglyceride measurement
3
72.9
mean corpuscular hemoglobin concentration
1
66.9
mathematical ability
1
66.3
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2384303
271209
Rat
RGD:1586886
683404
Dog
RP1 like 1
VGNC:45699
486085
Horse
RP1 like 1
VGNC:50757
100629161
Anole lizard
RP1 like 1
103278540
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
RP1 like 1
Horse
RP1 like 1
Anole lizard
RP1 like 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IWN7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (58)
1 – 10 of 58
MSRA
Tbio
Family: Enzyme
Novelty: 0.00595154
Score: 0.904
Data Source: STRINGDB
SOX7
Tbio
Family: TF
Novelty: 0.01269127
Score: 0.801
Data Source: STRINGDB
DCLK3
Tchem
Family: Kinase
Novelty: 0.00454456
Score: 0.688
Data Source: STRINGDB
ABCA4
Tbio
Family: Transporter
Novelty: 0.00162903
Score: 0.679
Data Source: STRINGDB
ZNF513
Tbio
Family: TF
Novelty: 0.86576929
Score: 0.668
Data Source: STRINGDB
PRSS55
Tbio
Family: Enzyme
Novelty: 0.20503445
Score: 0.657
Data Source: STRINGDB
PCARE
Tbio
Novelty: 0.0915146
Score: 0.631
Data Source: STRINGDB
EVC2
Tbio
Novelty: 0.01398469
Score: 0.575
Data Source: STRINGDB
C11orf88
Tdark
Novelty: 8.94681157
Score: 0.568
Data Source: STRINGDB
MAK
Tchem
Family: Kinase
Novelty: 0.04630863
Score: 0.568
Data Source: STRINGDB
Publication Statistics
PubMed Score  42.99

PubMed score by year
PubTator Score  21.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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