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Tbio
HSCB
Iron-sulfur cluster co-chaperone protein HscB, mitochondrial

Protein Summary
Description
Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria. This gene encodes a DnaJ-type co-chaperone and member of the heat shock cognate B (HscB) family of proteins. The encoded protein plays a role in the synthesis of iron-sulfur clusters, protein cofactors that are involved in the redox reactions of mitochondrial electron transport and other processes. Cells in which this gene is knocked down exhibit reduced activity of iron-sulfur cluster-dependent enzymes including succinate dehydrogenase and aconitase. The encoded protein may stimulate the ATPase activity of the mitochondrial stress-70 protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216027
  • ENSP00000216027
  • ENSG00000100209

Symbol
  • DNAJC20
  • HSC20
  • JAC1
  • HSC20
  • DNAJC20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
virus perturbation
0.85
transcription factor binding site profile
0.8
tissue sample
0.61
cellular component
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.67   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.67   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
48.9
red blood cell distribution width
1
1
1
6.3
triglyceride measurement
1
1
1
5.6
mean platelet volume
1
1
1
0.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
48.9
red blood cell distribution width
1
6.3
triglyceride measurement
1
5.6
mean platelet volume
1
0.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HscB mitochondrial iron-sulfur cluster cochaperone
VGNC:9923
458734
Macaque
HscB mitochondrial iron-sulfur cluster cochaperone
713734
Mouse
MGI:2141135
100900
Rat
RGD:1311005
360826
Dog
HscB mitochondrial iron-sulfur cluster cochaperone
VGNC:41796
477531
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HscB mitochondrial iron-sulfur cluster cochaperone
Macaque
HscB mitochondrial iron-sulfur cluster cochaperone
Mouse
Rat
Dog
HscB mitochondrial iron-sulfur cluster cochaperone
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8IWL3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Mitochondrial iron-sulfur cluster biogenesis
Reactome
Mitochondrial protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Metabolism
Mitochondrial iron-sulfur cluster biogenesis
Mitochondrial protein import
Protein localization
Gene Ontology Terms (12)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (140)
1 – 10 of 140
ISCU
Tbio
Novelty: 0.0043097
Score: 0.998
Data Source: STRINGDB
FXN
Tbio
Novelty: 0.00084064
Score: 0.993
Data Source: STRINGDB
ISCA2
Tbio
Novelty: 0.02194373
Score: 0.99
Data Source: STRINGDB
ISCA1
Tbio
Novelty: 0.01288069
Score: 0.989
Data Source: STRINGDB
HSPA9
Tbio
Novelty: 0.00235171
Score: 0.988
Data Source: STRINGDB
GLRX5
Tbio
Novelty: 0.01166161
Score: 0.988
Data Source: STRINGDB
GRPEL1
Tbio
Novelty: 0.00185346
Score: 0.982
Data Source: STRINGDB
NFS1
Tbio
Family: Enzyme
Novelty: 0.01274706
Score: 0.973
Data Source: STRINGDB
DNAJC19
Tbio
Family: Enzyme
Novelty: 0.02938164
Score: 0.971
Data Source: STRINGDB
PMPCB
Tbio
Family: Enzyme
Novelty: 0.0244013
Score: 0.965
Data Source: STRINGDB
Publication Statistics
PubMed Score  73.67

PubMed score by year
PubTator Score  20.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer