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Tbio
ADGRA3
Adhesion G protein-coupled receptor A3

Protein Summary
Description
Orphan receptor that may have a role in planar cell polarity pathway. This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334304
  • ENSP00000334952
  • ENSG00000152990
  • ENST00000502482
  • ENSP00000421006
  • ENST00000508133
  • ENSP00000422606

Symbol
  • GPR125
  • PGR21
  • TEM5L
  • GPR125
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
virus perturbation
1
kinase perturbation
0.71
tissue sample
0.71
histone modification site profile
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.15   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.15   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
inflammatory biomarker measurement
1
1
0
42.5
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
inflammatory biomarker measurement
0
42.5
17.8
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor A3
VGNC:551
471156
Mouse
MGI:1917943
70693
Rat
RGD:1304914
305408
Dog
adhesion G protein-coupled receptor A3
VGNC:37633
488859
Horse
adhesion G protein-coupled receptor A3
VGNC:15100
100068039
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor A3
Mouse
Rat
Dog
adhesion G protein-coupled receptor A3
Horse
adhesion G protein-coupled receptor A3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IWK6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
GDB
Protein-Protein Interactions (52)
1 – 10 of 52
IGDCC3
Tdark
Novelty:  0.01192143
Score:  0.793
Data Source:  STRINGDB
GFRA1
Tbio
Novelty:  0.00373994
Score:  0.768
Data Source:  STRINGDB
ADGRL1
Tbio
Family:  GPCR
Novelty:  0.00957739
Score:  0.764
Data Source:  STRINGDB
ADGRL2
Tbio
Family:  GPCR
Novelty:  0.00985539
Score:  0.757
Data Source:  STRINGDB
ADGRL3
Tbio
Family:  GPCR
Novelty:  0.00268343
Score:  0.745
Data Source:  STRINGDB
PACRGL
Tdark
Novelty:  1.16182573
Score:  0.736
Data Source:  STRINGDB
ADGRF2
Tdark
Family:  GPCR
Novelty:  0.35622722
Score:  0.668
Data Source:  STRINGDB
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
Score:  0.663
Data Source:  STRINGDB
THY1
Tbio
Novelty:  0.00032846
Score:  0.644
Data Source:  STRINGDB
ADGRG3
Tchem
Family:  GPCR
Novelty:  0.11719468
Score:  0.631
Data Source:  STRINGDB
Publication Statistics
PubMed Score  17.15

PubMed score by year
PubTator Score  9.25

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer