Tbio ADGRA3 Adhesion G protein-coupled receptor A3

Protein Summary

Description

Orphan receptor that may have a role in planar cell polarity pathway. This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2012]

Uniprot Accession IDs

• Q8IWK6
• Q6UXK9
• Q86SQ5
• Q8TC55

Gene Name

• ADGRA3

Ensembl ID

• ENST00000334304
• ENSP00000334952
• ENSG00000152990
• ENST00000502482
• ENSP00000421006
• ENST00000508133
• ENSP00000422606

Symbol

• GPR125
• PGR21
• TEM5L
• GPR125

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
virus perturbation	1
kinase perturbation	0.71
tissue sample	0.71
histone modification site profile	0.66

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Adhesion Class / Adhesion G Protein-coupled Receptor A3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.53   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 156   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.53   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0