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Tbio
ADGRA3
Adhesion G protein-coupled receptor A3

Protein Summary
Description
Orphan receptor that may have a role in planar cell polarity pathway. This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334304
  • ENSP00000334952
  • ENSG00000152990
  • ENST00000502482
  • ENSP00000421006
  • ENST00000508133
  • ENSP00000422606

Symbol
  • GPR125
  • PGR21
  • TEM5L
  • GPR125
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
virus perturbation
1
kinase perturbation
0.71
tissue sample
0.71
histone modification site profile
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.22   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.22   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
GDB
Protein-Protein Interactions (52)
1 – 10 of 52
IGDCC3
Tdark
Novelty: 0.140625
Score: 0.793
Data Source: STRINGDB
GFRA1
Tbio
Novelty: 0.0057944
Score: 0.768
Data Source: STRINGDB
ADGRL1
Tbio
Family: GPCR
Novelty: 0.01343585
Score: 0.764
Data Source: STRINGDB
ADGRL2
Tbio
Family: GPCR
Novelty: 0.01111728
Score: 0.757
Data Source: STRINGDB
ADGRL3
Tbio
Family: GPCR
Novelty: 0.00182297
Score: 0.745
Data Source: STRINGDB
PACRGL
Tdark
Novelty: 7
Score: 0.736
Data Source: STRINGDB
ADGRF2
Tdark
Family: GPCR
Novelty: 1.76986065
Score: 0.668
Data Source: STRINGDB
ADGRG5
Tdark
Family: GPCR
Novelty: 0.38877844
Score: 0.663
Data Source: STRINGDB
THY1
Tbio
Novelty: 0.00046162
Score: 0.644
Data Source: STRINGDB
ADGRG3
Tchem
Family: GPCR
Novelty: 0.12992476
Score: 0.631
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.22

PubMed score by year
PubTator Score  9.25

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer