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Tbio
GCC2
GRIP and coiled-coil domain-containing protein 2

Protein Summary
Description
Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2. The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309863
  • ENSP00000307939
  • ENSG00000135968
  • ENST00000482325
  • ENSP00000419969

Symbol
  • KIAA0336
  • RANBP2L4
  • REN53
  • GCC185
  • RANBP2L4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
transcription factor binding site profile
0.72
cell line
0.68
virus perturbation
0.68
biological process
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.45   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.45   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
1
1
37.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
37.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
GRIP and coiled-coil domain containing 2
693729
Mouse
MGI:1917547
70297
Rat
RGD:1305732
309798
Dog
GRIP and coiled-coil domain containing 2
VGNC:41140
474541
Horse
GRIP and coiled-coil domain containing 2
VGNC:18271
100061081
Species
Name
OMA
EggNOG
Inparanoid
Macaque
GRIP and coiled-coil domain containing 2
Mouse
Rat
Dog
GRIP and coiled-coil domain containing 2
Horse
GRIP and coiled-coil domain containing 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8IWJ2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (536)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Retrograde transport at the Trans-Golgi-Network
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Retrograde transport at the Trans-Golgi-Network
Vesicle-mediated transport
Gene Ontology Terms (15)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (132)
1 – 10 of 132
EXOC3
Tbio
Novelty: 0.01051955
p_int: 0.999999996
p_ni: 3e-9
Score: 0.19
Data Source: BioPlex,STRINGDB
SSC5D
Tbio
Novelty: 0.23138499
p_int: 0.999999553
p_ni: 4.47e-7
Score: 0.206
Data Source: BioPlex,STRINGDB
PMF1
Tbio
Novelty: 0.05319446
p_int: 0.999999371
p_ni: 6.29e-7
Data Source: BioPlex
WASHC3
Tdark
Novelty: 0.18307321
p_int: 0.999998314
p_ni: 0.000001686
Data Source: BioPlex
CCDC136
Tbio
Novelty: 0.09279967
p_int: 0.999996515
p_ni: 0.000003485
Score: 0.564
Data Source: BioPlex,STRINGDB
HINT3
Tdark
Novelty: 1.14285714
p_int: 0.999984583
p_ni: 0.000015417
Data Source: BioPlex
BRK1
Tbio
Novelty: 0.02289534
p_int: 0.999983316
p_ni: 0.000016684
Data Source: BioPlex
TTC4
Tbio
Novelty: 0.00808711
p_int: 0.99996431
p_ni: 0.00003569
Score: 0.542
Data Source: BioPlex,STRINGDB
CCDC107
Tdark
Novelty: 1.10682722
p_int: 0.99992694
p_ni: 0.00007306
Data Source: BioPlex
BCAS2
Tbio
Novelty: 0.05425016
p_int: 0.999747457
p_ni: 0.000252543
Data Source: BioPlex
Publication Statistics
PubMed Score  27.45

PubMed score by year
PubTator Score  15.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer