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Tbio
MGA
MAX gene-associated protein

Protein Summary
Description
Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219905
  • ENSP00000219905
  • ENSG00000174197
  • ENST00000545763
  • ENSP00000442467
  • ENST00000566586
  • ENSP00000456141
  • ENST00000570161
  • ENSP00000457035

Symbol
  • KIAA0518
  • MAD5
  • MAD5
  • MXD5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.89
transcription factor
0.82
transcription factor perturbation
0.68
kinase perturbation
0.66
co-expressed gene
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.58   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 59   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.58   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
1
1
1
74.6
body mass index
1
1
1
60.5
BMI-adjusted waist-hip ratio
2
1
2
44.6
FEV/FEC ratio
1
1
1
38.5
feeling nervous measurement
1
1
0
5.7
17.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
1
74.6
body mass index
1
60.5
BMI-adjusted waist-hip ratio
2
44.6
FEV/FEC ratio
1
38.5
feeling nervous measurement
0
5.7
17.2
Pathways (5)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Transcriptional Regulation by E2F6
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Transcriptional Regulation by E2F6
Protein-Protein Interactions (77)
1 – 10 of 77
PCGF6
Tbio
Novelty: 0.07032909
p_int: 0.999999679
p_ni: 3.21e-7
Score: 0.985
Data Source: BioPlex,Reactome,STRINGDB
L3MBTL2
Tbio
Family: Epigenetic
Novelty: 0.11193867
p_int: 0.999996757
p_ni: 0.000003243
Score: 0.973
Data Source: BioPlex,Reactome,STRINGDB
MAX
Tbio
Family: TF
Novelty: 0.00799068
p_int: 0.999990365
p_ni: 0.000009635
Score: 0.949
Data Source: BioPlex,Reactome,STRINGDB
CRYBG2
Tdark
Novelty: 0.7500462
p_int: 0.999857734
p_ni: 0.000142267
Score: 0.311
Data Source: BioPlex,STRINGDB
MIER2
Tbio
Novelty: 0.85226416
p_int: 0.999820734
p_ni: 0.000179266
Score: 0.622
Data Source: BioPlex,STRINGDB
RYBP
Tbio
Novelty: 0.01140945
p_int: 0.999796035
p_ni: 0.000203964
Score: 0.726
Data Source: BioPlex,STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
p_int: 0.999647717
p_ni: 0.000352283
Score: 0.225
Data Source: BioPlex,STRINGDB
E2F6
Tbio
Family: TF
Novelty: 0.00753541
p_int: 0.998990381
p_ni: 0.00100961
p_wrong: 8e-9
Score: 0.986
Data Source: BioPlex,Reactome,STRINGDB
WDR5
Tchem
Novelty: 0.0059945
p_int: 0.998951978
p_ni: 0.001048022
Score: 0.952
Data Source: BioPlex,STRINGDB
HSPB2
Tbio
Novelty: 0.00103909
p_int: 0.997485411
p_ni: 0.002514589
Data Source: BioPlex
Publication Statistics
PubMed Score  9.58

PubMed score by year
PubTator Score  28.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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