You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DENND6A
Protein DENND6A

Protein Summary
Description
Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311128
  • ENSP00000311401
  • ENSG00000174839

Symbol
  • FAM116A
  • AFI1A
  • FAM116A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.74
tissue sample
0.67
microRNA
0.66
histone modification site profile
0.65
virus perturbation
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.34   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.34   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
RPS6KC1
Tdark
Family:  Kinase
Novelty:  0.33998272
p_int:  0.999999997
p_ni:  2e-9
Score:  0.419
Data Source:  BioPlex,STRINGDB
DENND6B
Tbio
Novelty:  1.49514544
p_int:  0.999977319
p_wrong:  0.000022681
Data Source:  BioPlex
HAVCR2
Tbio
Novelty:  0.00155885
p_int:  0.999953759
p_ni:  0.000046241
Data Source:  BioPlex
TPCN2
Tchem
Family:  IC
Novelty:  0.01351129
p_int:  0.999695866
p_ni:  0.000304134
Data Source:  BioPlex
TGFBR2
Tchem
Family:  Kinase
Novelty:  0.00085381
p_int:  0.998203843
p_ni:  0.001796156
p_wrong:  1e-9
Data Source:  BioPlex
EML3
Tdark
Novelty:  0.26210133
p_int:  0.996420565
p_ni:  0.003579434
p_wrong:  1e-9
Data Source:  BioPlex
EFNB2
Tbio
Novelty:  0.00255095
p_int:  0.995868608
p_ni:  0.004124167
p_wrong:  0.000007225
Data Source:  BioPlex
BTN2A1
Tbio
Novelty:  0.02259329
p_int:  0.993338119
p_ni:  0.006660443
p_wrong:  0.000001438
Data Source:  BioPlex
PDCD1
Tclin
Novelty:  0.000448
p_int:  0.991856325
p_ni:  0.008141345
p_wrong:  0.000002331
Data Source:  BioPlex
TPK1
Tbio
Family:  Kinase
Novelty:  0.00899463
p_int:  0.99094282
p_ni:  0.00423727
p_wrong:  0.00481991
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
Rab regulation of trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
RAB GEFs exchange GTP for GDP on RABs
Rab regulation of trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
21.5
heel bone mineral density
1
1
1
12.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
21.5
heel bone mineral density
1
12.9
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DENN domain containing 6A
VGNC:7967
460472
Macaque
DENN domain containing 6A
707616
Mouse
MGI:2442980
211922
Rat
RGD:1306064
306229
Dog
DENN domain containing 6A
VGNC:39895
476578
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DENN domain containing 6A
Macaque
DENN domain containing 6A
Mouse
Rat
Dog
DENN domain containing 6A
Publication Statistics
PubMed Score 0.34
PubMed score by year
PubTator Score 0.20
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title