Tbio DENND6A Protein DENND6A

Protein Summary

Description

Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes.

Uniprot Accession IDs

• Q8IWF6
• Q7Z5T4
• Q8N235
• Q8TEG8

Gene Name

• DENND6A

Ensembl ID

• ENST00000311128
• ENSP00000311401
• ENSG00000174839

Symbol

• FAM116A
• AFI1A
• FAM116A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.74
tissue sample	0.67
microRNA	0.66
histone modification site profile	0.65
virus perturbation	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.34   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 50   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.34   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (35)

Explore Interacting Targets

1 – 10 of 35

• See Interactions on String-DB

RPS6KC1

Tdark

Family:  Kinase

Novelty:  0.33998272

p_int:  0.999999997

p_ni:  2e-9

Score:  0.419

Data Source:  BioPlex,STRINGDB

DENND6B

Tbio

Novelty:  1.49514544

p_int:  0.999977319

p_wrong:  0.000022681

Data Source:  BioPlex

HAVCR2

Tbio

Novelty:  0.00155885

p_int:  0.999953759

p_ni:  0.000046241

Data Source:  BioPlex

TPCN2

Tchem

Family:  IC

Novelty:  0.01351129

p_int:  0.999695866

p_ni:  0.000304134

Data Source:  BioPlex

TGFBR2

Tchem

Family:  Kinase

Novelty:  0.00085381

p_int:  0.998203843

p_ni:  0.001796156

p_wrong:  1e-9

Data Source:  BioPlex

EML3

Tdark

Novelty:  0.26210133

p_int:  0.996420565

p_ni:  0.003579434

p_wrong:  1e-9

Data Source:  BioPlex

EFNB2

Tbio

Novelty:  0.00255095

p_int:  0.995868608

p_ni:  0.004124167

p_wrong:  0.000007225

Data Source:  BioPlex

BTN2A1

Tbio

Novelty:  0.02259329

p_int:  0.993338119

p_ni:  0.006660443

p_wrong:  0.000001438

Data Source:  BioPlex

PDCD1

Tclin

Novelty:  0.000448

p_int:  0.991856325

p_ni:  0.008141345

p_wrong:  0.000002331

Data Source:  BioPlex

TPK1

Tbio

Family:  Kinase

Novelty:  0.00899463

p_int:  0.99094282

p_ni:  0.00423727

p_wrong:  0.00481991

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (4)

Membrane Trafficking (R-HSA-199991)

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Membrane Trafficking	612 targets	R-HSA-199991
Reactome	RAB GEFs exchange GTP for GDP on RABs	90 targets	R-HSA-8876198
Reactome	Rab regulation of trafficking	123 targets	R-HSA-9007101
Reactome	Vesicle-mediated transport	725 targets	R-HSA-5653656

Name	Explore in Pharos	Explore in Source
Membrane Trafficking	612 targets	R-HSA-199991
RAB GEFs exchange GTP for GDP on RABs	90 targets	R-HSA-8876198
Rab regulation of trafficking	123 targets	R-HSA-9007101
Vesicle-mediated transport	725 targets	R-HSA-5653656

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Functions (1)

Components (4)

Processes (1)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
Rab guanyl-nucleotide exchange factor activity	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
chronic obstructive pulmonary disease	EFO_0000341	1	1	0	1.1	21.5
heel bone mineral density	EFO_0009270	1	1	1		12.9

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
chronic obstructive pulmonary disease	EFO_0000341	0	1.1	21.5
heel bone mineral density	EFO_0009270	1		12.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Cytoplasm
Endosome
Guanine-nucleotide releasing factor
Methylation
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
chronic obstructive pulmonary disease
heel bone mineral density

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	DENN domain containing 6A	VGNC:7967	460472
Macaque	DENN domain containing 6A		707616
Mouse	DENN/MADD domain containing 6A	MGI:2442980	211922
Rat	DENN domain containing 6A	RGD:1306064	306229
Dog	DENN domain containing 6A	VGNC:39895	476578

Species	Name	OMA	EggNOG	Inparanoid
Chimp	DENN domain containing 6A
Macaque	DENN domain containing 6A
Mouse	DENN/MADD domain containing 6A
Rat	DENN domain containing 6A
Dog	DENN domain containing 6A

Publication Statistics

PubMed Score 0.34

PubMed score by year

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PubTator Score 0.20

PubTator score by year

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Related Publications

Text Mined References (6)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title