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Tdark
DCUN1D3
DCN1-like protein 3

Protein Summary
Description
Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane (PubMed:25349211). When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar (PubMed:25349211).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324344
  • ENSP00000319482
  • ENSG00000188215
  • ENST00000563934
  • ENSP00000454762

Symbol
  • SCCRO3
  • 44M2.4
  • SCCRO3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
transcription factor binding site profile
0.84
transcription factor
0.68
histone modification site profile
0.64
tissue sample
0.63


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.95   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.95   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2679003
233805
Rat
RGD:1308893
309035
Dog
defective in cullin neddylation 1 domain containing 3
VGNC:39823
489983
Horse
defective in cullin neddylation 1 domain containing 3
VGNC:17064
100058079
Cow
defective in cullin neddylation 1 domain containing 3
VGNC:27937
504926
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
defective in cullin neddylation 1 domain containing 3
Horse
defective in cullin neddylation 1 domain containing 3
Cow
defective in cullin neddylation 1 domain containing 3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8IWE4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Protein-Protein Interactions (168)
1 – 10 of 168
ASB2
Tbio
Novelty: 0.02852942
p_int: 0.998984586
p_ni: 0.000001728
p_wrong: 0.001013686
Score: 0.966
Data Source: BioPlex,STRINGDB
UBE2F
Tbio
Novelty: 0.06951245
Score: 0.998
Data Source: STRINGDB
UBE2M
Tbio
Novelty: 0.02353106
Score: 0.988
Data Source: STRINGDB
RBX1
Tbio
Family: Enzyme
Novelty: 0.00596986
Score: 0.981
Data Source: Reactome,STRINGDB
CAND1
Tbio
Novelty: 0.0196525
Score: 0.979
Data Source: STRINGDB
NEDD8
Tbio
Novelty: 0.00305343
Score: 0.977
Data Source: STRINGDB
RNF7
Tbio
Novelty: 0.02532658
Score: 0.975
Data Source: STRINGDB
CUL1
Tbio
Novelty: 0.00244476
Score: 0.975
Data Source: Reactome,STRINGDB
CUL3
Tbio
Novelty: 0.0028737
Score: 0.974
Data Source: STRINGDB
CUL2
Tbio
Novelty: 0.00512916
Score: 0.96
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.95

PubMed score by year
PubTator Score  3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer