Tchem DCUN1D3 DCN1-like protein 3

Protein Summary

Description

Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane (PubMed:25349211). When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar (PubMed:25349211).

Uniprot Accession IDs

• Q8IWE4
• B3KVY4

Gene Name

• DCUN1D3

Ensembl ID

• ENST00000324344
• ENSP00000319482
• ENSG00000188215
• ENST00000563934
• ENSP00000454762

Symbol

• SCCRO3
• 44M2.4
• SCCRO3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.98
transcription factor binding site profile	0.84
transcription factor	0.68
histone modification site profile	0.64
tissue sample	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.29   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 64   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.29   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0