Protein Summary
Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane (PubMed:25349211). When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar (PubMed:25349211).
- ENST00000324344
- ENSP00000319482
- ENSG00000188215
- ENST00000563934
- ENSP00000454762
- SCCRO3
- 44M2.4
- SCCRO3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.98 | ||
transcription factor binding site profile | 0.84 | ||
transcription factor | 0.68 | ||
histone modification site profile | 0.64 | ||
tissue sample | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.95 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 64 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.95 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 64 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (168)
ASB2
Novelty: 0.02852942
p_int: 0.998984586
p_ni: 0.000001728
p_wrong: 0.001013686
Score: 0.966
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Neddylation | ||||
Reactome | Post-translational protein modification | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Neddylation | ||||
Post-translational protein modification | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (3)
Components (3)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
eosinophil count | 2 | 2 | 2 | 75.4 | |||||
eosinophil percentage of leukocytes | 1 | 1 | 1 | 61.4 | |||||
1 | 1 | 1 | 45.2 | ||||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil count | 2 | 75.4 | |||||
eosinophil percentage of leukocytes | 1 | 61.4 | |||||
1 | 45.2 | ||||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:2679003 | 233805 | ||||||
Rat | RGD:1308893 | 309035 | ||||||
Dog | defective in cullin neddylation 1 domain containing 3 | VGNC:39823 | 489983 | |||||
Horse | defective in cullin neddylation 1 domain containing 3 | VGNC:17064 | 100058079 | |||||
Cow | defective in cullin neddylation 1 domain containing 3 | VGNC:27937 | 504926 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | defective in cullin neddylation 1 domain containing 3 | |||||
Horse | defective in cullin neddylation 1 domain containing 3 | |||||
Cow | defective in cullin neddylation 1 domain containing 3 | |||||
Publication Statistics
PubMed Score 1.95
PubMed score by year
PubTator Score 3.00
PubTator score by year
Related Publications
Text Mined References (9)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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