Tdark DCUN1D3 DCN1-like protein 3

Protein Summary

Description

Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane (PubMed:25349211). When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar (PubMed:25349211).

Uniprot Accession IDs

• Q8IWE4
• B3KVY4

Gene Name

• DCUN1D3

Ensembl ID

• ENST00000324344
• ENSP00000319482
• ENSG00000188215
• ENST00000563934
• ENSP00000454762

Symbol

• SCCRO3
• 44M2.4
• SCCRO3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.98
transcription factor binding site profile	0.84
transcription factor	0.68
histone modification site profile	0.64
tissue sample	0.63

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.95   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 64   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.95   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)	MGI:2679003	233805
Rat	defective in cullin neddylation 1 domain containing 3	RGD:1308893	309035
Dog	defective in cullin neddylation 1 domain containing 3	VGNC:39823	489983
Horse	defective in cullin neddylation 1 domain containing 3	VGNC:17064	100058079
Cow	defective in cullin neddylation 1 domain containing 3	VGNC:27937	504926

Species	Name	OMA	EggNOG	Inparanoid
Mouse	DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
Rat	defective in cullin neddylation 1 domain containing 3
Dog	defective in cullin neddylation 1 domain containing 3
Horse	defective in cullin neddylation 1 domain containing 3
Cow	defective in cullin neddylation 1 domain containing 3

Protein Structure (1 Structure, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8IWE4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (3)

Reactome (3)

Metabolism of proteins (R-HSA-392499)

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Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Neddylation	234 targets	R-HSA-8951664
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592

Name	Explore in Pharos	Explore in Source
Metabolism of proteins	2050 targets	R-HSA-392499
Neddylation	234 targets	R-HSA-8951664
Post-translational protein modification	1450 targets	R-HSA-597592

Gene Ontology Terms (14)

Functions (3)

Components (3)

Processes (8)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
cullin family protein binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
ubiquitin conjugating enzyme binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
ubiquitin-like protein binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (168)

Explore Interacting Targets

1 – 10 of 168

• See Interactions on String-DB

ASB2

Tbio

Novelty: 0.02852942

p_int: 0.998984586

p_ni: 0.000001728

p_wrong: 0.001013686

Score: 0.966

Data Source: BioPlex,STRINGDB

UBE2F

Tbio

Novelty: 0.06951245

Score: 0.998

Data Source: STRINGDB

UBE2M

Tbio

Novelty: 0.02353106

Score: 0.988

Data Source: STRINGDB

RBX1

Tbio

Family: Enzyme

Novelty: 0.00596986

Score: 0.981

Data Source: Reactome,STRINGDB

CAND1

Tbio

Novelty: 0.0196525

Score: 0.979

Data Source: STRINGDB

NEDD8

Tbio

Novelty: 0.00305343

Score: 0.977

Data Source: STRINGDB

RNF7

Tbio

Novelty: 0.02532658

Score: 0.975

Data Source: STRINGDB

CUL1

Tbio

Novelty: 0.00244476

Score: 0.975

Data Source: Reactome,STRINGDB

CUL3

Tbio

Novelty: 0.0028737

Score: 0.974

Data Source: STRINGDB

CUL2

Tbio

Novelty: 0.00512916

Score: 0.96

Data Source: STRINGDB

Publication Statistics

PubMed Score  1.95

PubMed score by year

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PubTator Score  3

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Cell membrane
Complete proteome
Lipoprotein
Membrane
Myristate
Polymorphism
Reference proteome

MGI Phenotype Find Similar Targets

adipose tissue phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
mortality/aging
skeleton phenotype