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Tbio
SLC44A2
Choline transporter-like protein 2

Protein Summary
Description
Isoform 1, but not isoform 3, exhibits some choline transporter activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335757
  • ENSP00000336888
  • ENSG00000129353
  • ENST00000407327
  • ENSP00000385135
  • ENST00000586078
  • ENSP00000466664

Symbol
  • CTL2
  • CTL2
  • PP1292
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
transcription factor
0.71
tissue
0.64
tissue sample
0.64
molecular function
0.63


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.44   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.44   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
9
10
98.5
apolipoprotein B measurement
1
6
6
98
total cholesterol measurement
2
8
9
97.8
red blood cell distribution width
4
5
6
96.4
reticulocyte measurement
3
2
3
94.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
10
98.5
apolipoprotein B measurement
6
98
total cholesterol measurement
9
97.8
red blood cell distribution width
6
96.4
reticulocyte measurement
3
94.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 44 member 2
VGNC:7782
455711
Macaque
solute carrier family 44 member 2
715866
Mouse
MGI:1915932
68682
Rat
RGD:1309680
363024
Dog
solute carrier family 44 member 2
VGNC:46418
484951
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 44 member 2
Macaque
solute carrier family 44 member 2
Mouse
Rat
Dog
solute carrier family 44 member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IWA5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Immune System
Innate Immune System
Metabolism
Metabolism of lipids
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (120)
1 – 10 of 120
RP2
Tbio
Novelty:  0.12345247
p_int:  0.999999181
p_ni:  1.44e-7
p_wrong:  6.75e-7
Score:  0.313
Data Source:  BioPlex,STRINGDB
CD177
Tbio
Novelty:  0.00197563
Score:  0.937
Data Source:  STRINGDB
ITGAL
Tclin
Novelty:  0.00099016
Score:  0.935
Data Source:  STRINGDB
STK10
Tchem
Family:  Kinase
Novelty:  0.01536884
Score:  0.925
Data Source:  STRINGDB
ITGAM
Tbio
Novelty:  0.00017521
Score:  0.917
Data Source:  STRINGDB
SLC27A2
Tbio
Family:  Transporter
Novelty:  0.01436035
Score:  0.912
Data Source:  STRINGDB
SLC15A4
Tbio
Family:  Transporter
Novelty:  0.01325014
Score:  0.91
Data Source:  STRINGDB
SLC2A5
Tbio
Family:  Transporter
Novelty:  0.0032733
Score:  0.91
Data Source:  STRINGDB
SLCO4C1
Tchem
Family:  Transporter
Novelty:  0.04138167
Score:  0.909
Data Source:  STRINGDB
SLC2A3
Tchem
Family:  Transporter
Novelty:  0.00229395
Score:  0.909
Data Source:  STRINGDB
Publication Statistics
PubMed Score  74.44

PubMed score by year
PubTator Score  42.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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