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Tbio
MFN1
Mitofusin-1

Protein Summary
Description
Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303). Membrane clustering requires GTPase activity (PubMed:27920125). It may involve a major rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376). Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:12759376). Has low GTPase activity (PubMed:27920125, PubMed:28114303). The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263969
  • ENSP00000263969
  • ENSG00000171109
  • ENST00000357390
  • ENSP00000349963
  • ENST00000471841
  • ENSP00000420617

Symbol
  • hfzo1
  • hfzo2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
disease perturbation
0.99
transcription factor perturbation
0.94
molecular function
0.91
histone modification site profile
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.02   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.02   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
7.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
7.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitofusin 1
VGNC:2044
460861
Macaque
mitofusin 1
709570
Mouse
MGI:1914664
67414
Rat
RGD:621460
192647
Dog
mitofusin 1
VGNC:43192
488086
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitofusin 1
Macaque
mitofusin 1
Mouse
Rat
Dog
mitofusin 1
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8IWA4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
Macroautophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Factors involved in megakaryocyte development and platelet production
Hemostasis
Macroautophagy
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (142)
1 – 10 of 142
MFN2
Tbio
Novelty: 0.00137876
p_int: 0.99999989
p_ni: 1.08e-7
p_wrong: 2e-9
Score: 0.947
Data Source: BioPlex,STRINGDB
TOMM22
Tbio
Novelty: 0.01217913
p_int: 0.999978244
p_ni: 0.000021756
Score: 0.853
Data Source: BioPlex,STRINGDB
FAF2
Tbio
Novelty: 0.03048598
p_int: 0.999764983
p_ni: 0.000235017
Score: 0.2
Data Source: BioPlex,STRINGDB
FLNC
Tbio
Novelty: 0.00463205
p_int: 0.872742776
p_ni: 0.127257224
Score: 0.213
Data Source: BioPlex,STRINGDB
PRKN
Tbio
Family: Enzyme
Novelty: 0.00079898
Score: 0.99
Data Source: STRINGDB
PINK1
Tbio
Family: Kinase
Novelty: 0.00100973
Score: 0.987
Data Source: STRINGDB
VDAC1
Tbio
Novelty: 0.0011441
Score: 0.976
Data Source: STRINGDB
OPA1
Tbio
Novelty: 0.0031868
Score: 0.975
Data Source: STRINGDB
FIS1
Tbio
Novelty: 0.0033607
Score: 0.97
Data Source: STRINGDB
DNM1L
Tbio
Novelty: 0.00151314
Score: 0.959
Data Source: STRINGDB
Publication Statistics
PubMed Score  244.02

PubMed score by year
PubTator Score  96.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer