Tbio WDR75 WD repeat-containing protein 75

Protein Summary

Description

Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.

Uniprot Accession IDs

• Q8IWA0
• Q96J10
• Q9H8U8
• Q9H9U5
• Q9H9V8
• Q9UIX2

Gene Name

• WDR75

Ensembl ID

• ENST00000314761
• ENSP00000314193
• ENSG00000115368

Symbol

• UTP17
• NET16
• UTP17

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.94
ligand (protein) perturbation	0.83
histone modification site profile	0.81
virus perturbation	0.79
tissue	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.89   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 23   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.89   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0