Tbio ARHGEF19 Rho guanine nucleotide exchange factor 19

Protein Summary

Description

Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Guanine nucleotide exchange factors (GEFs) such as ARHGEF19 accelerate the GTPase activity of Rho GTPases (see RHOA, MIM 165390).[supplied by OMIM, Dec 2008]

Uniprot Accession IDs

• Q8IW93
• A6NJ04
• Q5TEV2
• Q6PJQ4
• Q8N244

Gene Name

• ARHGEF19

Ensembl ID

• ENST00000270747
• ENSP00000270747
• ENSG00000142632

Symbol

• WGEF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.84
tissue sample	0.66
cell type or tissue	0.58
protein domain	0.58
cell line	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.44   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 71   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.44   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (39)

Explore Interacting Targets

1 – 10 of 39

• See Interactions on String-DB

RHOA

Tbio

Family:  Enzyme

Novelty:  0.00022204

Score:  0.964

Data Source:  STRINGDB

CDC42

Tchem

Family:  Enzyme

Novelty:  0.00032619

Score:  0.95

Data Source:  STRINGDB

RAC1

Tbio

Family:  Enzyme

Novelty:  0.00365325

Score:  0.949

Data Source:  STRINGDB

RHOG

Tbio

Family:  Enzyme

Novelty:  0.00412327

Score:  0.944

Data Source:  STRINGDB

RHOD

Tbio

Family:  Enzyme

Novelty:  0.0029764

Score:  0.934

Data Source:  STRINGDB

RHOV

Tbio

Family:  Enzyme

Novelty:  0.02138482

Score:  0.929

Data Source:  STRINGDB

RAC3

Tbio

Family:  Enzyme

Novelty:  0.02125361

Score:  0.928

Data Source:  STRINGDB

RHOU

Tbio

Family:  Enzyme

Novelty:  0.01456329

Score:  0.926

Data Source:  STRINGDB

RHOBTB1

Tbio

Novelty:  0.02152609

Score:  0.926

Data Source:  STRINGDB

RHOJ

Tbio

Family:  Enzyme

Novelty:  0.01217051

Score:  0.926

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (10)

Reactome (10)

Cell death signalling via NRAGE, NRIF and NADE (R-HSA-204998)

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5

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell death signalling via NRAGE, NRIF and NADE	76 targets	R-HSA-204998
Reactome	Death Receptor Signalling	141 targets	R-HSA-73887
Reactome	G alpha (12/13) signalling events	80 targets	R-HSA-416482
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396
Reactome	NRAGE signals death through JNK	59 targets	R-HSA-193648

Name	Explore in Pharos	Explore in Source
Cell death signalling via NRAGE, NRIF and NADE	76 targets	R-HSA-204998
Death Receptor Signalling	141 targets	R-HSA-73887
G alpha (12/13) signalling events	80 targets	R-HSA-416482
GPCR downstream signalling	1152 targets	R-HSA-388396
NRAGE signals death through JNK	59 targets	R-HSA-193648

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Functions (3)

Components (1)

Processes (7)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
guanyl-nucleotide exchange factor activity	Traceable Author Statement (TAS)	Reactome
Rho guanyl-nucleotide exchange factor activity	Traceable Author Statement (TAS)	Reactome
GTPase activator activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (12)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 12

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum gamma-glutamyl transferase measurement	EFO_0004532	5	12	13	3.8	99.8
low density lipoprotein cholesterol measurement	EFO_0004611	5	3	5		88.3
aspartate aminotransferase measurement	EFO_0004736	2	2	1	13.2	83.6
balding measurement	EFO_0007825	1	1	1		67.1
serum albumin measurement	EFO_0004535	1	2	2		63

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 12

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum gamma-glutamyl transferase measurement	EFO_0004532	13	3.8	99.8
low density lipoprotein cholesterol measurement	EFO_0004611	5		88.3
aspartate aminotransferase measurement	EFO_0004736	1	13.2	83.6
balding measurement	EFO_0007825	1		67.1
serum albumin measurement	EFO_0004535	2		63

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
GTPase activation
Guanine-nucleotide releasing factor
Polymorphism
Reference proteome
SH3 domain

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein B measurement
aspartate aminotransferase measurement
balding measurement
facial morphology measurement
glomerular filtration rate
low density lipoprotein cholesterol measurement
serum alanine aminotransferase measurement
serum albumin measurement
serum gamma-glutamyl transferase measurement
sex hormone-binding globulin measurement

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	Rho guanine nucleotide exchange factor 19	VGNC:6720	469134
Mouse	Rho guanine nucleotide exchange factor (GEF) 19	MGI:1925912	213649
Dog	Rho guanine nucleotide exchange factor 19	VGNC:38079	100856630
Horse	Rho guanine nucleotide exchange factor 19	VGNC:15487	100053592
Cow	Rho guanine nucleotide exchange factor 19	VGNC:26110	617280

Species	Name	OMA	EggNOG	Inparanoid
Chimp	Rho guanine nucleotide exchange factor 19
Mouse	Rho guanine nucleotide exchange factor (GEF) 19
Dog	Rho guanine nucleotide exchange factor 19
Horse	Rho guanine nucleotide exchange factor 19
Cow	Rho guanine nucleotide exchange factor 19

Publication Statistics

PubMed Score 5.44

PubMed score by year

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PubTator Score 2.84

PubTator score by year

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Related Publications

Text Mined References (9)

GeneRif Annotations (3)

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10

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PMID	Year	Title