ARHGEF19
Rho guanine nucleotide exchange factor 19
Protein Summary
Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Guanine nucleotide exchange factors (GEFs) such as ARHGEF19 accelerate the GTPase activity of Rho GTPases (see RHOA, MIM 165390).[supplied by OMIM, Dec 2008]
- ENST00000270747
- ENSP00000270747
- ENSG00000142632
- WGEF
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.84 | ||
tissue sample | 0.66 | ||
cell type or tissue | 0.58 | ||
protein domain | 0.58 | ||
cell line | 0.57 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.44 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 71 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.44 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 71 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 5 | 12 | 13 | 3.8 | 99.8 | ||||
low density lipoprotein cholesterol measurement | 5 | 3 | 5 | 88.3 | |||||
aspartate aminotransferase measurement | 2 | 2 | 1 | 13.2 | 83.6 | ||||
balding measurement | 1 | 1 | 1 | 67.1 | |||||
serum albumin measurement | 1 | 2 | 2 | 63 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 13 | 3.8 | 99.8 | ||||
low density lipoprotein cholesterol measurement | 5 | 88.3 | |||||
aspartate aminotransferase measurement | 1 | 13.2 | 83.6 | ||||
balding measurement | 1 | 67.1 | |||||
serum albumin measurement | 2 | 63 | |||||
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | Rho guanine nucleotide exchange factor 19 | VGNC:6720 | 469134 | |||||
Mouse | MGI:1925912 | 213649 | ||||||
Dog | Rho guanine nucleotide exchange factor 19 | VGNC:38079 | 100856630 | |||||
Horse | Rho guanine nucleotide exchange factor 19 | VGNC:15487 | 100053592 | |||||
Cow | Rho guanine nucleotide exchange factor 19 | VGNC:26110 | 617280 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | Rho guanine nucleotide exchange factor 19 | |||||
Mouse | ||||||
Dog | Rho guanine nucleotide exchange factor 19 | |||||
Horse | Rho guanine nucleotide exchange factor 19 | |||||
Cow | Rho guanine nucleotide exchange factor 19 | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (10)
Reactome (10)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 10
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell death signalling via NRAGE, NRIF and NADE | ||||
Reactome | Death Receptor Signalling | ||||
Reactome | G alpha (12/13) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | NRAGE signals death through JNK | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell death signalling via NRAGE, NRIF and NADE | ||||
Death Receptor Signalling | ||||
G alpha (12/13) signalling events | ||||
GPCR downstream signalling | ||||
NRAGE signals death through JNK | ||||
Gene Ontology Terms (11)
Functions (3)
Components (1)
Processes (7)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (39)
1 – 10 of 39
RHOA
Family: Enzyme
Novelty: 0.00022204
Score: 0.964
Data Source: STRINGDB
CDC42
Family: Enzyme
Novelty: 0.00032619
Score: 0.95
Data Source: STRINGDB
RAC1
Family: Enzyme
Novelty: 0.00365325
Score: 0.949
Data Source: STRINGDB
RHOG
Family: Enzyme
Novelty: 0.00412327
Score: 0.944
Data Source: STRINGDB
RHOD
Family: Enzyme
Novelty: 0.0029764
Score: 0.934
Data Source: STRINGDB
RHOV
Family: Enzyme
Novelty: 0.02138482
Score: 0.929
Data Source: STRINGDB
RAC3
Family: Enzyme
Novelty: 0.02125361
Score: 0.928
Data Source: STRINGDB
RHOU
Family: Enzyme
Novelty: 0.01456329
Score: 0.926
Data Source: STRINGDB
RHOBTB1
Novelty: 0.02152609
Score: 0.926
Data Source: STRINGDB
RHOJ
Family: Enzyme
Novelty: 0.01217051
Score: 0.926
Data Source: STRINGDB
Publication Statistics
PubMed Score 5.44
PubMed score by year
PubTator Score 2.84
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
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GWAS Trait
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