Tbio ARHGEF19 Rho guanine nucleotide exchange factor 19

Protein Summary

Description

Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Guanine nucleotide exchange factors (GEFs) such as ARHGEF19 accelerate the GTPase activity of Rho GTPases (see RHOA, MIM 165390).[supplied by OMIM, Dec 2008]

Uniprot Accession IDs

• Q8IW93
• A6NJ04
• Q5TEV2
• Q6PJQ4
• Q8N244

Gene Name

• ARHGEF19

Ensembl ID

• ENST00000270747
• ENSP00000270747
• ENSG00000142632

Symbol

• WGEF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.84
tissue sample	0.66
cell type or tissue	0.58
protein domain	0.58
cell line	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.39   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 71   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.39   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0