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Tdark
SLITRK4
SLIT and NTRK-like protein 4

Protein Summary
Description
It is involved in synaptogenesis and promotes synapse differentiation (PubMed:27812321). Suppresses neurite outgrowth (By similarity). This gene encodes a transmembrane protein belonging to the the SLITRK family. These family members include two N-terminal leucine-rich repeat domains similar to those found in the axonal growth-controlling protein SLIT, as well as C-terminal regions similar to neurotrophin receptors. Studies of an homologous protein in mouse suggest that this family member functions to suppress neurite outgrowth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338017
  • ENSP00000336627
  • ENSG00000179542
  • ENST00000356928
  • ENSP00000349400
  • ENST00000596188
  • ENSP00000469205
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.71
tissue sample
0.65
cell type or tissue
0.6
protein domain
0.58
PubMedID
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.76   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 226   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.76   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
CNPY3
Tbio
Novelty:  0.11473132
p_int:  0.84889044
p_ni:  0.15110956
Score:  0.297
Data Source:  BioPlex,STRINGDB
PTPRD
Tbio
Family:  Enzyme
Novelty:  0.01059407
Score:  0.91
Data Source:  STRINGDB
IGHMBP2
Tbio
Novelty:  0.01054517
Score:  0.751
Data Source:  STRINGDB
ARHGEF37
Tdark
Novelty:  1.21184334
Score:  0.637
Data Source:  STRINGDB
ARHGAP42
Tbio
Family:  Enzyme
Novelty:  0.19934281
Score:  0.576
Data Source:  STRINGDB
PCDH12
Tbio
Novelty:  0.06268895
Score:  0.566
Data Source:  STRINGDB
ARHGEF40
Tdark
Novelty:  0.3458097
Score:  0.555
Data Source:  STRINGDB
LRR1
Tbio
Novelty:  0.02407468
Score:  0.537
Data Source:  STRINGDB
NLGN1
Tbio
Family:  Enzyme
Novelty:  0.0097512
Score:  0.534
Data Source:  STRINGDB
NLGN2
Tbio
Family:  Enzyme
Novelty:  0.01613168
Score:  0.526
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Reactome
Receptor-type tyrosine-protein phosphatases
Name
Explore in Pharos
Explore in Source
Neuronal System
Protein-protein interactions at synapses
Receptor-type tyrosine-protein phosphatases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatine kinase measurement
1
1
1
2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatine kinase measurement
1
2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SLIT and NTRK like family member 4
VGNC:11643
473810
Macaque
SLIT and NTRK like family member 4
698270
Mouse
MGI:2442509
245446
Dog
SLIT and NTRK like family member 4
VGNC:46509
492183
Horse
SLIT and NTRK like family member 4
VGNC:23303
100055730
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SLIT and NTRK like family member 4
Macaque
SLIT and NTRK like family member 4
Mouse
Dog
SLIT and NTRK like family member 4
Horse
SLIT and NTRK like family member 4
Publication Statistics
PubMed Score 3.76
PubMed score by year
PubTator Score 2.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title