MAPKAPK5
MAP kinase-activated protein kinase 5
Protein Classes
Protein Summary
Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4 ...more
- ENST00000550735
- ENSP00000449667
- ENSG00000089022
- ENST00000551404
- ENSP00000449381
- PRAK
- MK5
- MK-5
- PRAK
- MAPKAP-K5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.99 | ||
histone modification site profile | 0.9 | ||
transcription factor binding site profile | 0.83 | ||
kinase perturbation | 0.81 | ||
kinase | 0.8 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 83 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 547 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 83 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 547 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (5)
1 – 5 of 5
Pathways (93)
Reactome (13)
KEGG (1)
PathwayCommons (6)
WikiPathways (73)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 13
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cellular Senescence | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cellular Senescence | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Gene Ontology Terms (23)
Functions (7)
Components (4)
Processes (12)
Items per page:
10
1 – 7 of 7
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (71)
1 – 10 of 71
MAPK6
Family: Kinase
Novelty: 0.01585877
p_int: 0.999999998
p_ni: 1e-9
p_wrong: 2e-9
Score: 0.978
Data Source: BioPlex,Reactome,STRINGDB
MAPK4
Family: Kinase
Novelty: 0.04156197
p_int: 0.999999428
p_ni: 5.69e-7
p_wrong: 4e-9
Score: 0.967
Data Source: BioPlex,Reactome,STRINGDB
ZNF577
Family: TF
Novelty: 1.54411765
p_int: 0.999611145
p_ni: 0.000388854
p_wrong: 1e-9
Data Source: BioPlex
TP53
Family: TF
Novelty: 0.00002203
Score: 0.99
Data Source: Reactome,STRINGDB
HSPB1
Novelty: 0.00095687
Score: 0.984
Data Source: Reactome,STRINGDB
MAPK11
Family: Kinase
Novelty: 0.00860226
Score: 0.968
Data Source: Reactome,STRINGDB
MAPK14
Family: Kinase
Novelty: 0.00018655
Score: 0.968
Data Source: Reactome,STRINGDB
MYC
Family: TF
Novelty: 0.000073
Score: 0.952
Data Source: STRINGDB
MAPK12
Family: Kinase
Novelty: 0.01020422
Score: 0.938
Data Source: STRINGDB
MAPK13
Family: Kinase
Novelty: 0.00235189
Score: 0.927
Data Source: STRINGDB
Publication Statistics
PubMed Score 83.00
PubMed score by year
PubTator Score 48.08
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Sequence
MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKARNEVRLHMMCA
1-70
THPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCH
70-140
LLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIP
140-210
TSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDV
210-280
VRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLK
280-350
PLHSVNNPILRKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGKGENEDEKLNEVMQ
350-420
EAWKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
420-473
MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKARNEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGKGENEDEKLNEVMQEAWKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
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