MAPKAPK5
MAP kinase-activated protein kinase 5
Protein Summary
Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4 ...more
- ENST00000550735
- ENSP00000449667
- ENSG00000089022
- ENST00000551404
- ENSP00000449381
- PRAK
- MK5
- MK-5
- PRAK
- MAPKAP-K5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.99 | ||
histone modification site profile | 0.9 | ||
transcription factor binding site profile | 0.83 | ||
kinase perturbation | 0.81 | ||
kinase | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 86.94 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 547 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 86.94 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 547 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 6
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (6)
Protein-Protein Interactions (71)
MAPK6
Family: Kinase
Novelty: 0.01012514
p_int: 0.999999998
p_ni: 1e-9
p_wrong: 2e-9
Score: 0.978
Data Source: BioPlex,Reactome,STRINGDB
MAPK4
Family: Kinase
Novelty: 0.0223868
p_int: 0.999999428
p_ni: 5.69e-7
p_wrong: 4e-9
Score: 0.967
Data Source: BioPlex,Reactome,STRINGDB
ZNF577
Family: TF
Novelty: 0.29636548
p_int: 0.999611145
p_ni: 0.000388854
p_wrong: 1e-9
Data Source: BioPlex
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (93)
Reactome (13)
KEGG (1)
PathwayCommons (6)
WikiPathways (73)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cellular Senescence | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cellular Senescence | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (7)
Components (4)
Processes (12)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (44)
Items per page:
1 – 5 of 44
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
3 | 2 | 0 | 1.9 | 93.2 | |||||
alcohol consumption measurement | 2 | 1 | 1 | 2.5 | 88.6 | ||||
2 | 2 | 0 | 1.6 | 88.5 | |||||
drinking behavior | 1 | 1 | 0 | 6.3 | 88.2 | ||||
coffee consumption measurement | 1 | 1 | 1 | 87.8 | |||||
Items per page:
1 – 5 of 44
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.9 | 93.2 | |||||
alcohol consumption measurement | 1 | 2.5 | 88.6 | ||||
0 | 1.6 | 88.5 | |||||
drinking behavior | 0 | 6.3 | 88.2 | ||||
coffee consumption measurement | 1 | 87.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | mitogen-activated protein kinase-activated protein kinase 5 | 713521 | ||||||
Mouse | MGI:1333110 | 17165 | ||||||
Rat | RGD:1564113 | 498183 | ||||||
Dog | mitogen-activated protein kinase-activated protein kinase 5 | VGNC:43008 | 477480 | |||||
Horse | mitogen-activated protein kinase-activated protein kinase 5 | VGNC:19968 | 100057579 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | mitogen-activated protein kinase-activated protein kinase 5 | |||||
Mouse | ||||||
Rat | ||||||
Dog | mitogen-activated protein kinase-activated protein kinase 5 | |||||
Horse | mitogen-activated protein kinase-activated protein kinase 5 | |||||
Publication Statistics
PubMed Score 86.94
PubMed score by year
PubTator Score 48.08
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (39)
GeneRif Annotations (15)
Items per page:
0 of 0
PMID | Year | Title |
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