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Tchem
MAPKAPK5
MAP kinase-activated protein kinase 5

Protein Summary
Description
Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000550735
  • ENSP00000449667
  • ENSG00000089022
  • ENST00000551404
  • ENSP00000449381

Symbol
  • PRAK
  • MK5
  • MK-5
  • PRAK
  • MAPKAP-K5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
histone modification site profile
0.9
transcription factor binding site profile
0.83
kinase perturbation
0.81
kinase
0.8


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.08   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 547   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.08   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 547   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
25.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
25.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
mitogen-activated protein kinase-activated protein kinase 5
713521
Mouse
MGI:1333110
17165
Rat
RGD:1564113
498183
Dog
mitogen-activated protein kinase-activated protein kinase 5
VGNC:43008
477480
Horse
mitogen-activated protein kinase-activated protein kinase 5
VGNC:19968
100057579
Species
Name
OMA
EggNOG
Inparanoid
Macaque
mitogen-activated protein kinase-activated protein kinase 5
Mouse
Rat
Dog
mitogen-activated protein kinase-activated protein kinase 5
Horse
mitogen-activated protein kinase-activated protein kinase 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IW41-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (93)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Gene expression (Transcription)
Generic Transcription Pathway
Gene Ontology Terms (23)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (71)
1 – 10 of 71
MAPK6
Tbio
Family: Kinase
Novelty: 0.01012514
p_int: 0.999999998
p_ni: 1e-9
p_wrong: 2e-9
Score: 0.978
Data Source: BioPlex,Reactome,STRINGDB
MAPK4
Tbio
Family: Kinase
Novelty: 0.0223868
p_int: 0.999999428
p_ni: 5.69e-7
p_wrong: 4e-9
Score: 0.967
Data Source: BioPlex,Reactome,STRINGDB
ZNF577
Tdark
Family: TF
Novelty: 0.29636548
p_int: 0.999611145
p_ni: 0.000388854
p_wrong: 1e-9
Data Source: BioPlex
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.99
Data Source: Reactome,STRINGDB
HSPB1
Tchem
Novelty: 0.00081373
Score: 0.984
Data Source: Reactome,STRINGDB
MAPK11
Tchem
Family: Kinase
Novelty: 0.00545217
Score: 0.968
Data Source: Reactome,STRINGDB
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
Score: 0.968
Data Source: Reactome,STRINGDB
MYC
Tbio
Family: TF
Novelty: 0.00005734
Score: 0.952
Data Source: STRINGDB
MAPK12
Tchem
Family: Kinase
Novelty: 0.00835017
Score: 0.938
Data Source: STRINGDB
MAPK13
Tchem
Family: Kinase
Novelty: 0.01071621
Score: 0.927
Data Source: STRINGDB
Publication Statistics
PubMed Score  83.08

PubMed score by year
PubTator Score  48.08

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer