You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
APLF
Aprataxin and PNK-like factor

Protein Summary
Description
Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage. C2ORF13 is a component of the cellular response to chromosomal DNA single- and double-strand breaks (Iles et al., 2007 [PubMed 17353262]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303795
  • ENSP00000307004
  • ENSG00000169621

Symbol
  • C2orf13
  • PALF
  • XIP1
  • APFL
  • PALF
  • Xip1
  • ZCCHH1
  • C2orf13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.87
histone modification site profile
0.84
molecular function
0.79
transcription factor binding site profile
0.74
microRNA
0.66


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 330   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 330   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1919353
72103
Rat
RGD:1565557
500247
Dog
aprataxin and PNKP like factor
VGNC:53960
481405
Horse
aprataxin and PNKP like factor
VGNC:51276
100061683
Cow
aprataxin and PNKP like factor
507989
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
aprataxin and PNKP like factor
Horse
aprataxin and PNKP like factor
Cow
aprataxin and PNKP like factor
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (15)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (79)
1 – 10 of 79
POLB
Tchem
Family: Enzyme
Novelty: 0.00145102
p_int: 1
Score: 0.835
Data Source: BioPlex,STRINGDB
XRCC6
Tbio
Novelty: 0.00127955
p_int: 0.999999999
p_ni: 1e-9
Score: 0.992
Data Source: BioPlex,STRINGDB
LIG3
Tbio
Family: Enzyme
Novelty: 0.00809038
p_int: 0.999999909
p_ni: 9.1e-8
Score: 0.766
Data Source: BioPlex,STRINGDB
XRCC1
Tbio
Novelty: 0.00084203
p_int: 0.999996794
p_ni: 0.000003205
p_wrong: 2e-9
Score: 0.986
Data Source: BioPlex,STRINGDB
XPC
Tbio
Novelty: 0.00775175
p_int: 0.999982116
p_ni: 0.000017884
Score: 0.78
Data Source: BioPlex,STRINGDB
PARP2
Tclin
Family: Enzyme
Novelty: 0.00545618
p_int: 0.999977284
p_ni: 0.000022716
Score: 0.822
Data Source: BioPlex,STRINGDB
H2AFY2
Tbio
Novelty: 0.09948698
p_int: 0.999964233
p_ni: 0.000035757
p_wrong: 1e-8
Score: 0.551
Data Source: BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty: 0.02431803
p_int: 0.999931503
p_ni: 0.00006523
p_wrong: 0.000003267
Score: 0.671
Data Source: BioPlex,STRINGDB
LIG4
Tbio
Family: Enzyme
Novelty: 0.00412993
p_int: 0.999849717
p_ni: 0.000124037
p_wrong: 0.000026246
Score: 0.989
Data Source: BioPlex,STRINGDB
TDP1
Tchem
Family: Enzyme
Novelty: 0.00607344
p_int: 0.99969278
p_ni: 0.000304918
p_wrong: 0.000002303
Score: 0.776
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  71.00

PubMed score by year
PubTator Score  36.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer