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Tdark
C1orf210
Type III endosome membrane protein TEMP

Protein Summary
Description
May be involved in membrane trafficking between endosomes and plasma membrane.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000423420
  • ENSP00000429399
  • ENSG00000253313
  • ENST00000523677
  • ENSP00000430918

Symbol
  • TEMP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.32   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.32   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
4
4
92.3
platelet crit
2
3
4
88.5
asparaginase-induced acute pancreatitis
1
1
0
4.6
30.2
hemoglobin measurement
2
1
2
30.1
hematocrit
2
1
2
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
92.3
platelet crit
4
88.5
asparaginase-induced acute pancreatitis
0
4.6
30.2
hemoglobin measurement
2
30.1
hematocrit
2
21.5
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1913701
66451
Rat
RGD:1305347
362576
Dog
chromosome 1 open reading frame 210 [Source:HGNC Symbol;Acc:HGNC:28755]
Horse
chromosome 2 C1orf210 homolog
VGNC:50657
100630016
Cow
chromosome 3 C1orf210 homolog
VGNC:52710
509100
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
chromosome 1 open reading frame 210 [Source:HGNC Symbol;Acc:HGNC:28755]
Horse
chromosome 2 C1orf210 homolog
Cow
chromosome 3 C1orf210 homolog
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IVY1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (9)
1 – 9 of 9
MAPK8IP2
Tbio
Family:  Enzyme
Novelty:  0.01788453
Score:  0.556
Data Source:  STRINGDB
RARS2
Tbio
Family:  Enzyme
Novelty:  0.01185296
Score:  0.531
Data Source:  STRINGDB
GPN2
Tdark
Family:  Enzyme
Novelty:  0.26461894
Score:  0.528
Data Source:  STRINGDB
BTBD10
Tbio
Novelty:  0.23077172
Score:  0.501
Data Source:  STRINGDB
ARID3A
Tbio
Family:  TF
Novelty:  0.01428989
Score:  0.475
Data Source:  STRINGDB
SEPT8
Tbio
Novelty:  0.01431499
Score:  0.469
Data Source:  STRINGDB
TICAM2
Tbio
Novelty:  0.04205084
Score:  0.454
Data Source:  STRINGDB
PRDX2
Tbio
Novelty:  0.00189751
Score:  0.422
Data Source:  STRINGDB
CWC22
Tbio
Novelty:  0.027689
Score:  0.42
Data Source:  STRINGDB
Publication Statistics
PubMed Score  5.32

PubMed score by year
PubTator Score  53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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