Tbio SPNS2 Protein spinster homolog 2

Protein Summary

Description

Sphingolipid transporter required for migration of myocardial precursors. Transports sphingosine 1-phosphate (S1P), a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration. The protein encoded by this gene is a transporter of sphingosine 1-phosphate, a secreted lipid that is important in cardiovascular, immunological, and neural development. Defects in this gene are a cause of early onset progressive hearing loss. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q8IVW8
• B9A1T3

Gene Name

• SPNS2

Ensembl ID

• ENST00000329078
• ENSP00000333292
• ENSG00000183018

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phenotype	0.64
tissue sample	0.58
gene perturbation	0.56
transcription factor	0.49
biological process	0.48

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc63 Sphingosine-phosphate Transporters / Protein Spinster Homolog 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.05   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 112   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.05   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0