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Tchem
CDKL3
Cyclin-dependent kinase-like 3

Protein Summary
Description
The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265334
  • ENSP00000265334
  • ENSG00000006837
  • ENST00000523832
  • ENSP00000430496

Symbol
  • NKIAMRE
  • NKIAMRE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
transcription factor binding site profile
0.81
virus perturbation
0.79
transcription factor
0.74
protein domain
0.73


Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.56   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.56   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
AST-487
Rendered image for AST-487
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
44.2
eosinophil count
1
1
1
6.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
44.2
eosinophil count
1
6.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase like 3
VGNC:6840
462064
Macaque
cyclin dependent kinase like 3
710586
Mouse
MGI:2388268
213084
Rat
RGD:11405961
108348323
Horse
cyclin dependent kinase like 3
VGNC:16360
100072771
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase like 3
Macaque
cyclin dependent kinase like 3
Mouse
Rat
Horse
cyclin dependent kinase like 3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8IVW4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (14)
1 – 10 of 14
STAMBP
Tchem
Novelty:  0.01543821
p_int:  0.99999148
p_ni:  0.00000852
Score:  0.516
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.751461821
p_ni:  0.248538179
Data Source:  BioPlex
LAMA4
Tbio
Novelty:  0.01288371
Score:  0.647
Data Source:  STRINGDB
ALG2
Tbio
Family:  Enzyme
Novelty:  0.03804805
Score:  0.626
Data Source:  STRINGDB
COX15
Tbio
Family:  Enzyme
Novelty:  0.02252282
Score:  0.61
Data Source:  STRINGDB
ADCK1
Tchem
Family:  Kinase
Novelty:  0.31158074
Score:  0.552
Data Source:  STRINGDB
PAXX
Tbio
Novelty:  0.03754932
Score:  0.517
Data Source:  STRINGDB
PI4KB
Tchem
Family:  Kinase
Novelty:  0.00856875
Score:  0.466
Data Source:  STRINGDB
ZNF473
Tbio
Family:  TF
Novelty:  0.07957644
Score:  0.461
Data Source:  STRINGDB
PRELID3A
Tbio
Novelty:  1.54594896
Score:  0.458
Data Source:  STRINGDB
Publication Statistics
PubMed Score  13.56

PubMed score by year
PubTator Score  5.95

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer