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Tbio
GID4
Glucose-induced degradation protein 4 homolog

Protein Summary
Description
Substrate-recognition subunit of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (Probable) (PubMed:29911972). Binds proteins and peptides with a Pro/N-degron consisting of an unmodified N-terminal Pro followed by a small residue, and has the highest affinity for the peptide Pro-Gly-Leu-Trp (PubMed:29632410). Binds peptides with an N-terminal sequence of the type Pro-[Ala,Gly]-[Leu,Met,Gln,Ser,Tyr]-[Glu,Gly,His,Ser,Val,Trp,Tyr]. Does not bind peptides with an acetylated N-terminal Pro residue (PubMed:29632410). The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268719
  • ENSP00000268719
  • ENSG00000141034

Symbol
  • C17orf39
  • VID24
  • VID2
  • VID24
  • C17orf39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
transcription factor perturbation
0.84
transcription factor binding site profile
0.8
small molecule perturbation
0.71
microRNA
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.88   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.88   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (84)
1 – 10 of 84
BMP1
Tchem
Novelty:  0.00299518
p_int:  0.999119473
p_ni:  0.000880527
Data Source:  BioPlex
RMND5A
Tbio
Novelty:  0.01820349
p_int:  0.999111161
p_ni:  0.000888839
Score:  0.971
Data Source:  BioPlex,STRINGDB
GCG
Tchem
Novelty:  0.00004879
p_int:  0.999036121
p_ni:  0.000963879
Data Source:  BioPlex
TDGF1
Tbio
Novelty:  0.00527099
p_int:  0.99888559
p_ni:  0.00111441
Score:  0.232
Data Source:  BioPlex,STRINGDB
TIGD5
Tdark
Novelty:  1.93340494
p_int:  0.998781563
p_ni:  0.001218437
Data Source:  BioPlex
INSL6
Tdark
Novelty:  0.06986187
p_int:  0.998158188
p_ni:  0.001841812
Data Source:  BioPlex
PRG3
Tbio
Novelty:  0.09431986
p_int:  0.996454882
p_ni:  0.003545118
Data Source:  BioPlex
MRPL18
Tbio
Novelty:  0.73438796
p_int:  0.991445281
p_ni:  0.008554719
Data Source:  BioPlex
DDX50
Tbio
Family:  Enzyme
Novelty:  0.05314506
p_int:  0.989891991
p_ni:  0.010108009
Data Source:  BioPlex
GPS2
Tbio
Novelty:  0.00986158
p_int:  0.988612548
p_ni:  0.011387452
Score:  0.187
Data Source:  BioPlex,STRINGDB
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
93.9
waist-hip ratio
2
5
5
84.1
BMI-adjusted waist-hip ratio
2
4
4
79.8
HbA1c measurement
1
1
1
68.8
red blood cell density measurement
1
1
1
67.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
93.9
waist-hip ratio
5
84.1
BMI-adjusted waist-hip ratio
4
79.8
HbA1c measurement
1
68.8
red blood cell density measurement
1
67.9
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
GID complex subunit 4 homolog
699842
Mouse
MGI:1914021
66771
Dog
GID complex subunit 4 homolog
VGNC:49858
479524
Horse
GID complex subunit 4 homolog [Source:HGNC Symbol;Acc:HGNC:28453]
Cow
GID complex subunit 4 homolog
509503
Species
Name
OMA
EggNOG
Inparanoid
Macaque
GID complex subunit 4 homolog
Mouse
Dog
GID complex subunit 4 homolog
Horse
GID complex subunit 4 homolog [Source:HGNC Symbol;Acc:HGNC:28453]
Cow
GID complex subunit 4 homolog
Publication Statistics
PubMed Score 21.88
PubMed score by year
PubTator Score 4.05
PubTator score by year