You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
KSR1
Kinase suppressor of Ras 1

Protein Summary
Description
Scaffolding protein that is part of a multiprotein signaling complex. Promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Does not have kinase activity by itself.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398988
  • ENSP00000381958
  • ENSG00000141068
  • ENST00000509603
  • ENSP00000438795

Symbol
  • KSR
  • KSR
  • RSU2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
molecular function
0.99
protein complex
0.99
hub protein
0.88
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.01   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 385   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.01   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 385   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (48)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
FLT3 Signaling
Immune System
Gene Ontology Terms (21)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (142)
1 – 10 of 142
P4HA1
Tchem
Family: Enzyme
Novelty: 0.02187424
p_int: 0.999982188
p_ni: 0.000017812
Data Source: BioPlex
PRMT2
Tbio
Family: Epigenetic
Novelty: 0.05650489
p_int: 0.999851867
p_ni: 0.000145671
p_wrong: 0.000002462
Score: 0.201
Data Source: BioPlex,STRINGDB
SDF4
Tbio
Novelty: 0.00130572
p_int: 0.998710774
p_ni: 0.001085184
p_wrong: 0.000204042
Score: 0.188
Data Source: BioPlex,STRINGDB
SKAP1
Tbio
Family: Enzyme
Novelty: 0.04762826
p_int: 0.997916549
p_ni: 0.001347322
p_wrong: 0.000736129
Score: 0.187
Data Source: BioPlex,STRINGDB
MAP2K1
Tclin
Family: Kinase
Novelty: 0.00072552
Score: 0.995
Data Source: Reactome,STRINGDB
CNKSR2
Tbio
Family: Enzyme
Novelty: 0.07140952
Score: 0.994
Data Source: STRINGDB
MAP2K2
Tclin
Family: Kinase
Novelty: 0.01210207
Score: 0.994
Data Source: Reactome,STRINGDB
CNKSR1
Tbio
Family: Enzyme
Novelty: 0.09218546
Score: 0.989
Data Source: STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00046573
Score: 0.981
Data Source: Reactome,STRINGDB
RAF1
Tclin
Family: Kinase
Novelty: 0.00165174
Score: 0.97
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  158.01

PubMed score by year
PubTator Score  109.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: