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Tbio
GLYCTK
Glycerate kinase

Protein Summary
Description
This locus encodes a member of the glycerate kinase type-2 family. The encoded enzyme catalyzes the phosphorylation of (R)-glycerate and may be involved in serine degradation and fructose metabolism. Decreased activity of the encoded enzyme may be associated with the disease D-glyceric aciduria. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305690
  • ENSP00000301965
  • ENSG00000168237
  • ENST00000436784
  • ENSP00000389175
  • ENST00000473032
  • ENSP00000418951
  • ENST00000477382
  • ENSP00000419008

Symbol
  • HBEBP4
  • HBEBP2
  • HBEBP4
  • HBeAgBP4A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
transcription factor
0.76
transcription factor binding site profile
0.69
virus perturbation
0.68
histone modification site profile
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.87   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.87   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
59.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
59.3
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycerate kinase
VGNC:6292
460420
Macaque
glycerate kinase
697521
Mouse
MGI:2444085
235582
Rat
RGD:1591498
684314
Horse
glycerate kinase
VGNC:18398
100060316
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycerate kinase
Macaque
glycerate kinase
Mouse
Rat
Horse
glycerate kinase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IVS8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Fructose catabolism (R-HSA-70350)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fructose catabolism
Reactome
Fructose metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Fructose catabolism
Fructose metabolism
Metabolism
Metabolism of carbohydrates
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (73)
1 – 10 of 73
GRHPR
Tbio
Family: Enzyme
Novelty: 0.01375508
Score: 0.978
Data Source: STRINGDB
ALDH9A1
Tbio
Family: Enzyme
Novelty: 0.01688006
Score: 0.931
Data Source: STRINGDB
ALDH1B1
Tbio
Family: Enzyme
Novelty: 0.01755208
Score: 0.922
Data Source: STRINGDB
ALDH3A2
Tbio
Family: Enzyme
Novelty: 0.0059198
Score: 0.919
Data Source: STRINGDB
ALDH7A1
Tbio
Family: Enzyme
Novelty: 0.00069494
Score: 0.915
Data Source: STRINGDB
TPI1
Tbio
Family: Enzyme
Novelty: 0.00074652
Score: 0.915
Data Source: STRINGDB
ALDH2
Tclin
Family: Enzyme
Novelty: 0.00077122
Score: 0.914
Data Source: STRINGDB
PGAM4
Tbio
Family: Enzyme
Novelty: 0.03784125
Score: 0.91
Data Source: STRINGDB
PGAM1
Tbio
Family: Enzyme
Novelty: 0.0111272
Score: 0.907
Data Source: STRINGDB
ADPGK
Tbio
Family: Kinase
Novelty: 0.0552414
Score: 0.905
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.87

PubMed score by year
PubTator Score  7.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer