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Tbio
FUNDC1
FUN14 domain-containing protein 1

Protein Summary
Description
Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control. This gene encodes a protein with a FUN14 superfamily domain. The function of the encoded protein is not known. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378045
  • ENSP00000367284
  • ENSG00000069509
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.67
cellular component
0.66
tissue sample
0.61
transcription factor perturbation
0.61
transcription factor binding site profile
0.58


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ARCHS4
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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.46   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.46   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1919268
72018
Rat
RGD:1563372
363442
Dog
FUN14 domain containing 1
VGNC:41007
491842
Horse
FUN14 domain containing 1
VGNC:18154
100059599
Cow
FUN14 domain containing 1
VGNC:29143
518258
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
FUN14 domain containing 1
Horse
FUN14 domain containing 1
Cow
FUN14 domain containing 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8IVP5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Reactome
Mitophagy
Reactome
Receptor Mediated Mitophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Mitophagy
Receptor Mediated Mitophagy
Protein-Protein Interactions (66)
1 – 10 of 66
METTL9
Tdark
Family: Enzyme
Novelty: 0.20589257
p_int: 0.998068977
p_ni: 0.000002112
p_wrong: 0.00192891
Data Source: BioPlex
FUNDC2
Tbio
Novelty: 0.09695817
p_int: 0.997508764
p_ni: 7e-8
p_wrong: 0.002491166
Score: 0.527
Data Source: BioPlex,STRINGDB
TMED8
Tdark
Novelty: 1.41977071
p_int: 0.84970648
p_ni: 0.000008363
p_wrong: 0.150285157
Data Source: BioPlex
MAP1LC3B
Tbio
Novelty: 0.00101276
Score: 0.996
Data Source: Reactome,STRINGDB
PGAM5
Tbio
Family: Enzyme
Novelty: 0.02046532
Score: 0.97
Data Source: Reactome,STRINGDB
MAP1LC3A
Tbio
Novelty: 0.00301583
Score: 0.962
Data Source: Reactome,STRINGDB
ULK1
Tchem
Family: Kinase
Novelty: 0.00240301
Score: 0.955
Data Source: Reactome,STRINGDB
ATG5
Tbio
Novelty: 0.00081472
Score: 0.951
Data Source: Reactome,STRINGDB
GABARAPL1
Tbio
Novelty: 0.00212657
Score: 0.938
Data Source: STRINGDB
CSNK2A2
Tchem
Family: Kinase
Novelty: 0.00231447
Score: 0.937
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  48.46

PubMed score by year
PubTator Score  11.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer