Tbio FUNDC1 FUN14 domain-containing protein 1

Protein Summary

Description

Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control. This gene encodes a protein with a FUN14 superfamily domain. The function of the encoded protein is not known. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• Q8IVP5

Gene Name

• FUNDC1

Ensembl ID

• ENST00000378045
• ENSP00000367284
• ENSG00000069509

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.67
cellular component	0.66
tissue sample	0.61
transcription factor perturbation	0.61
transcription factor binding site profile	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.4   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 190   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.4   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0