You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
SBSPON
Somatomedin-B and thrombospondin type-1 domain-containing protein

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297354
  • ENSP00000297354
  • ENSG00000164764

Symbol
  • C8orf84
  • RPESP
  • RPESP
  • C8orf84
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.74
cell type or tissue
0.6
cell line
0.59
tissue sample
0.59
transcription factor perturbation
0.47


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.63   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.63   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
28.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
28.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
somatomedin B and thrombospondin type 1 domain containing
VGNC:14583
748352
Mouse
MGI:2684952
226866
Rat
RGD:1559717
297757
Dog
somatomedin B and thrombospondin type 1 domain containing
VGNC:45886
610426
Cow
somatomedin B and thrombospondin type 1 domain containing
VGNC:34311
525332
Species
Name
OMA
EggNOG
Inparanoid
Chimp
somatomedin B and thrombospondin type 1 domain containing
Mouse
Rat
Dog
somatomedin B and thrombospondin type 1 domain containing
Cow
somatomedin B and thrombospondin type 1 domain containing
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IVN8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Metabolism of proteins
Protein-Protein Interactions (47)
1 – 10 of 47
ZNF609
Tdark
Novelty: 0.06635612
p_int: 0.986852259
p_ni: 0.013147737
p_wrong: 4e-9
Score: 0.416
Data Source: BioPlex,STRINGDB
ZNF703
Tbio
Novelty: 0.03956045
p_int: 0.870844578
p_ni: 0.129155414
p_wrong: 8e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
GFER
Tchem
Family: Enzyme
Novelty: 0.00338563
p_int: 0.793818863
p_ni: 0.206070172
p_wrong: 0.000110965
Score: 0.187
Data Source: BioPlex,STRINGDB
ADAMTSL4
Tbio
Novelty: 0.03890484
Score: 0.907
Data Source: STRINGDB
ADAMTSL3
Tbio
Novelty: 0.07699522
Score: 0.903
Data Source: STRINGDB
ADAMTS12
Tbio
Family: Enzyme
Novelty: 0.03184816
Score: 0.902
Data Source: STRINGDB
ADAMTS18
Tbio
Family: Enzyme
Novelty: 0.03614004
Score: 0.902
Data Source: STRINGDB
ADAMTS16
Tbio
Family: Enzyme
Novelty: 0.06909971
Score: 0.902
Data Source: STRINGDB
ADAMTS9
Tbio
Family: Enzyme
Novelty: 0.01447959
Score: 0.902
Data Source: STRINGDB
ADAMTS20
Tbio
Family: Enzyme
Novelty: 0.0416108
Score: 0.902
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.63

PubMed score by year
PubTator Score  1.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer