P3H3
Prolyl 3-hydroxylase 3
Protein Summary
Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Required for normal hydroxylation of lysine residues in type I collagen chains in skin, bone, tendon, aorta and cornea. Required for normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly. Apparently not required for normal prolyl 3-hydroxylation on collagen chains, possibly because it functions redundantly with other prolyl 3-hydroxylases. The protein encoded by this gene belongs to the leprecan family of proteoglycans, which function as collagen prolyl hydroxylases that are required for proper collagen biosynthesis, folding and assembly. This protein, like other family members, is thought to reside in the endoplasmic reticulum. Epigenetic inactivation of this gene is associated with breast and other cancers, suggest ...more
- ENST00000290510
- ENSP00000478600
- ENSG00000110811
- LEPREL2
- GRCB
- LEPREL2
- HSU47926
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue | 0.87 | ||
molecular function | 0.81 | ||
gene perturbation | 0.73 | ||
cellular component | 0.61 | ||
tissue sample | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 883.04 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 98 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 883.04 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 98 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (107)
COLQ
Family: Enzyme
Novelty: 0.01414634
p_int: 0.99968181
p_ni: 0.00031819
Score: 0.195
Data Source: BioPlex,STRINGDB
PLOD1
Family: Enzyme
Novelty: 0.00905345
p_int: 0.997593374
p_ni: 0.002406626
Score: 0.428
Data Source: BioPlex,STRINGDB
KNG1
Novelty: 0.00007684
p_int: 0.994106249
p_ni: 0.005893751
Score: 0.17
Data Source: BioPlex,STRINGDB
KEAP1
Novelty: 0.00062812
p_int: 0.981224285
p_ni: 0.018775715
Score: 0.173
Data Source: BioPlex,STRINGDB
C1QTNF2
Novelty: 0.18607978
p_int: 0.968902547
p_ni: 0.031097452
p_wrong: 1e-9
Data Source: BioPlex
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Collagen biosynthesis and modifying enzymes | ||||
Reactome | Collagen formation | ||||
Reactome | Extracellular matrix organization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Collagen biosynthesis and modifying enzymes | ||||
Collagen formation | ||||
Extracellular matrix organization | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (3)
Components (2)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 5 | 2 | 9 | 86.1 | |||||
refractive error measurement | 2 | 1 | 1 | 7.8 | 82.4 | ||||
age at onset | 1 | 1 | 0 | 7.8 | 63.4 | ||||
Myopia | 3 | 1 | 0 | 1.3 | 63.4 | ||||
ganglion cell inner plexiform layer thickness measurement | 1 | 1 | 1 | 58.4 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 9 | 86.1 | |||||
refractive error measurement | 1 | 7.8 | 82.4 | ||||
age at onset | 0 | 7.8 | 63.4 | ||||
Myopia | 0 | 1.3 | 63.4 | ||||
ganglion cell inner plexiform layer thickness measurement | 1 | 58.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (1)
1 – 1 of 1
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:1315208 | 14789 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Publication Statistics
PubMed Score 883.04
PubMed score by year
PubTator Score 41.02
PubTator score by year
Related Publications
Text Mined References (11)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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