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Tbio
P3H3
Prolyl 3-hydroxylase 3

Protein Summary
Description
Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Required for normal hydroxylation of lysine residues in type I collagen chains in skin, bone, tendon, aorta and cornea. Required for normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly. Apparently not required for normal prolyl 3-hydroxylation on collagen chains, possibly because it functions redundantly with other prolyl 3-hydroxylases. The protein encoded by this gene belongs to the leprecan family of proteoglycans, which function as collagen prolyl hydroxylases that are required for proper collagen biosynthesis, folding and assembly. This protein, like other family members, is thought to reside in the endoplasmic reticulum. Epigenetic inactivation of this gene is associated with breast and other cancers, suggest ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290510
  • ENSP00000478600
  • ENSG00000110811

Symbol
  • LEPREL2
  • GRCB
  • LEPREL2
  • HSU47926
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.87
molecular function
0.81
gene perturbation
0.73
cellular component
0.61
tissue sample
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 883.04   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 883.04   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
5
2
9
86.1
refractive error measurement
2
1
1
7.8
82.4
age at onset
1
1
0
7.8
63.4
Myopia
3
1
0
1.3
63.4
ganglion cell inner plexiform layer thickness measurement
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
9
86.1
refractive error measurement
1
7.8
82.4
age at onset
0
7.8
63.4
Myopia
0
1.3
63.4
ganglion cell inner plexiform layer thickness measurement
1
58.4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IVL6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Collagen biosynthesis and modifying enzymes
Collagen formation
Extracellular matrix organization
Gene Ontology Terms (9)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (107)
1 – 10 of 107
COLQ
Tbio
Family:  Enzyme
Novelty:  0.01414634
p_int:  0.99968181
p_ni:  0.00031819
Score:  0.195
Data Source:  BioPlex,STRINGDB
HRG
Tbio
Novelty:  0.0027048
p_int:  0.999324356
p_ni:  0.000675644
Data Source:  BioPlex
PLOD1
Tbio
Family:  Enzyme
Novelty:  0.00905345
p_int:  0.997593374
p_ni:  0.002406626
Score:  0.428
Data Source:  BioPlex,STRINGDB
DCAF8L2
Tdark
Novelty:  6.73057868
p_int:  0.995629364
p_ni:  0.004370636
Data Source:  BioPlex
KNG1
Tbio
Novelty:  0.00007684
p_int:  0.994106249
p_ni:  0.005893751
Score:  0.17
Data Source:  BioPlex,STRINGDB
SFTPA2
Tbio
Novelty:  0.00283745
p_int:  0.982384134
p_ni:  0.017615866
Data Source:  BioPlex
KEAP1
Tclin
Novelty:  0.00062812
p_int:  0.981224285
p_ni:  0.018775715
Score:  0.173
Data Source:  BioPlex,STRINGDB
SCGB2A2
Tbio
Novelty:  0.01594053
p_int:  0.981102415
p_ni:  0.018897585
Data Source:  BioPlex
C1QTNF9B
Tdark
Novelty:  0.7643008
p_int:  0.973747059
p_ni:  0.026252941
Data Source:  BioPlex
C1QTNF2
Tbio
Novelty:  0.18607978
p_int:  0.968902547
p_ni:  0.031097452
p_wrong:  1e-9
Data Source:  BioPlex
Publication Statistics
PubMed Score  883.04

PubMed score by year
PubTator Score  41.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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