Tbio P3H3 Prolyl 3-hydroxylase 3

Protein Summary

Description

Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Required for normal hydroxylation of lysine residues in type I collagen chains in skin, bone, tendon, aorta and cornea. Required for normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly. Apparently not required for normal prolyl 3-hydroxylation on collagen chains, possibly because it functions redundantly with other prolyl 3-hydroxylases. The protein encoded by this gene belongs to the leprecan family of proteoglycans, which function as collagen prolyl hydroxylases that are required for proper collagen biosynthesis, folding and assembly. This protein, like other family members, is thought to reside in the endoplasmic reticulum. Epigenetic inactivation of this gene is associated with breast and other cancers, suggesting that it may function as a tumor suppressor. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• Q8IVL6
• Q13512
• Q15740
• Q66K32
• Q6NX61
• Q7L2T1

Gene Name

• P3H3

Ensembl ID

• ENST00000290510
• ENSP00000478600
• ENSG00000110811

Symbol

• LEPREL2
• GRCB
• LEPREL2
• HSU47926

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.87
molecular function	0.81
gene perturbation	0.73
cellular component	0.61
tissue sample	0.6

Protein Classes

PANTHER Classes

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / Prolyl 3-hydroxylase 3

DTO Classes

Protein / Extracellular Structure / Extracellular Matrix Glycoprotein / Prolyl 3-hydroxylase 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 863.87   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 98   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 863.87   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0