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Tbio
NAV2
Neuron navigator 2

Protein Summary
Description
Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349880
  • ENSP00000309577
  • ENSG00000166833
  • ENST00000360655
  • ENSP00000353871
  • ENST00000396085
  • ENSP00000379394
  • ENST00000396087
  • ENSP00000379396
  • ENST00000533917
  • ENSP00000437316

Symbol
  • HELAD1
  • KIAA1419
  • POMFIL2
  • RAINB1
  • STEERIN2
  • HELAD1
  • RAINB1
  • POMFIL2
  • UNC53H2
  • STEERIN2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.99
molecular function
0.95
virus perturbation
0.92
transcription factor perturbation
0.88
transcription factor
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.66   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.66   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
3
0
1.1
88.6
serum gamma-glutamyl transferase measurement
1
1
1
54.4
mean reticulocyte volume
1
1
1
51.4
synophrys measurement
1
1
1
49.5
mean corpuscular volume
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
88.6
serum gamma-glutamyl transferase measurement
1
54.4
mean reticulocyte volume
1
51.4
synophrys measurement
1
49.5
mean corpuscular volume
1
39.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuron navigator 2
VGNC:3097
451076
Macaque
neuron navigator 2
702146
Mouse
MGI:2183691
78286
Rat
RGD:619778
171563
Dog
neuron navigator 2
VGNC:43630
485411
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuron navigator 2
Macaque
neuron navigator 2
Mouse
Rat
Dog
neuron navigator 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8IVL1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (14)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (18)
1 – 10 of 18
CNN1
Tbio
Novelty:  0.00813104
Score:  0.71
Data Source:  STRINGDB
TCF7L1
Tbio
Family:  TF
Novelty:  0.03807371
Score:  0.559
Data Source:  STRINGDB
E2F7
Tbio
Family:  TF
Novelty:  0.00797578
Score:  0.529
Data Source:  STRINGDB
PTPRM
Tchem
Family:  Enzyme
Novelty:  0.03504812
Score:  0.527
Data Source:  STRINGDB
TRIO
Tbio
Family:  Kinase
Novelty:  0.03113573
Score:  0.493
Data Source:  STRINGDB
TMEM132A
Tdark
Novelty:  0.26489093
Score:  0.478
Data Source:  STRINGDB
KCNC2
Tclin
Family:  IC
Novelty:  0.02509313
Score:  0.472
Data Source:  STRINGDB
DDR2
Tchem
Family:  Kinase
Novelty:  0.00358332
Score:  0.462
Data Source:  STRINGDB
SCN7A
Tclin
Family:  IC
Novelty:  0.05343818
Score:  0.461
Data Source:  STRINGDB
SYT1
Tbio
Novelty:  0.00176103
Score:  0.46
Data Source:  STRINGDB
Publication Statistics
PubMed Score  55.66

PubMed score by year
PubTator Score  16.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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