Tbio NOSTRIN Nostrin

Protein Summary

Description

Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane. Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004]

Uniprot Accession IDs

• Q8IVI9
• A8K2I9
• B3KSF5
• E7EPT9
• Q27HG3
• Q53S62
• Q96CJ9

Gene Name

• NOSTRIN

Ensembl ID

• ENST00000317647
• ENSP00000318921
• ENSG00000163072
• ENST00000397206
• ENSP00000380390
• ENST00000397209
• ENSP00000380392
• ENST00000444448
• ENSP00000394051
• ENST00000445023
• ENSP00000404413
• ENST00000458381
• ENSP00000402140

Symbol

• DaIP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.85
PubMedID	0.71
kinase perturbation	0.66
cellular component	0.65
tissue sample	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.72   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 178   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.72   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0