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Tbio
NOSTRIN
Nostrin

Protein Summary
Description
Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane. Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317647
  • ENSP00000318921
  • ENSG00000163072
  • ENST00000397206
  • ENSP00000380390
  • ENST00000397209
  • ENSP00000380392
  • ENST00000444448
  • ENSP00000394051
  • ENST00000445023
  • ENSP00000404413
  • ENST00000458381
  • ENSP00000402140

Symbol
  • DaIP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
PubMedID
0.71
kinase perturbation
0.66
cellular component
0.65
tissue sample
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.74   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.74   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
NOS3
Tchem
Family:  Enzyme
Novelty:  0.00012407
Score:  0.984
Data Source:  Reactome,STRINGDB
DNM2
Tchem
Novelty:  0.00265965
Score:  0.948
Data Source:  Reactome,STRINGDB
CAV1
Tbio
Novelty:  0.00035244
Score:  0.941
Data Source:  Reactome,STRINGDB
WASL
Tbio
Novelty:  0.0029314
Score:  0.929
Data Source:  Reactome,STRINGDB
MARS2
Tbio
Family:  Enzyme
Novelty:  0.02533315
Score:  0.797
Data Source:  STRINGDB
NOSIP
Tbio
Family:  Enzyme
Novelty:  0.05605921
Score:  0.737
Data Source:  STRINGDB
GLB1L
Tdark
Family:  Enzyme
Novelty:  0.43027328
Score:  0.731
Data Source:  STRINGDB
GLB1L2
Tdark
Family:  Enzyme
Novelty:  1.03866932
Score:  0.731
Data Source:  STRINGDB
GLB1
Tchem
Family:  Enzyme
Novelty:  0.00241713
Score:  0.731
Data Source:  STRINGDB
GLB1L3
Tdark
Family:  Enzyme
Novelty:  1.00833616
Score:  0.731
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nitric oxide: eNOS activation and regulation
Reactome
NOSTRIN mediated eNOS trafficking
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nitric oxide: eNOS activation and regulation
NOSTRIN mediated eNOS trafficking
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glucose measurement
8
30
33
100
HbA1c measurement
12
25
29
99.9
fasting blood glucose measurement
16
8
20
1.3
99.6
myeloid white cell count
2
2
2
91
monocyte count
3
2
3
90.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glucose measurement
33
100
HbA1c measurement
29
99.9
fasting blood glucose measurement
20
1.3
99.6
myeloid white cell count
2
91
monocyte count
3
90.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nitric oxide synthase trafficking
VGNC:14321
459712
Macaque
nitric oxide synthase trafficking
705063
Mouse
MGI:3606242
329416
Rat
RGD:727920
311111
Dog
nitric oxide synthase trafficking
VGNC:43897
478780
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nitric oxide synthase trafficking
Macaque
nitric oxide synthase trafficking
Mouse
Rat
Dog
nitric oxide synthase trafficking
Publication Statistics
PubMed Score 21.74
PubMed score by year
PubTator Score 10.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title