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Tchem
MAP4K3
Mitogen-activated protein kinase kinase kinase kinase 3

Protein Summary
Description
May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263881
  • ENSP00000263881
  • ENSG00000011566
  • ENST00000341681
  • ENSP00000345434

Symbol
  • RAB8IPL1
  • GLK
  • MEKKK3
  • MEKKK 3
  • MAPKKKK3
  • RAB8IPL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
protein domain
0.85
transcription factor binding site profile
0.8
histone modification site profile
0.75
cell type or tissue
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.51   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 325   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.51   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (10)
staurosporine
Rendered image for staurosporine
CHEMBL2086760
Rendered image for CHEMBL2086760
CHEMBL4793665
Rendered image for CHEMBL4793665
CHEMBL4780798
Rendered image for CHEMBL4780798
CHEMBL4778959
Rendered image for CHEMBL4778959
CHEMBL4749141
Rendered image for CHEMBL4749141
CHEMBL4762312
Rendered image for CHEMBL4762312
CHEMBL4753188
Rendered image for CHEMBL4753188
CHEMBL4782885
Rendered image for CHEMBL4782885
CHEMBL4568440
Rendered image for CHEMBL4568440
Protein-Protein Interactions (48)
IL13RA1
Tbio
Novelty:  0.03308775
p_int:  0.999999599
p_ni:  3.7e-7
p_wrong:  3.1e-8
Score:  0.622
Data Source:  BioPlex,STRINGDB
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.999994412
p_ni:  0.000005543
p_wrong:  4.6e-8
Score:  0.186
Data Source:  BioPlex,STRINGDB
MAP4K5
Tchem
Family:  Kinase
Novelty:  0.04848162
p_int:  0.999990388
p_ni:  0.000009144
p_wrong:  4.68e-7
Score:  0.655
Data Source:  BioPlex,STRINGDB
DBNL
Tbio
Novelty:  0.03390948
Score:  0.948
Data Source:  STRINGDB
MAP3K1
Tchem
Family:  Kinase
Novelty:  0.0041131
Score:  0.92
Data Source:  STRINGDB
TNF
Tclin
Novelty:  0.00001457
Score:  0.919
Data Source:  STRINGDB
MAP3K3
Tchem
Family:  Kinase
Novelty:  0.01607002
Score:  0.918
Data Source:  STRINGDB
MAP3K8
Tchem
Family:  Kinase
Novelty:  0.00581582
Score:  0.911
Data Source:  STRINGDB
MAP3K2
Tchem
Family:  Kinase
Novelty:  0.01201472
Score:  0.909
Data Source:  STRINGDB
TRAF2
Tbio
Novelty:  0.00983658
Score:  0.908
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
2
64
hemoglobin measurement
2
2
2
61.5
total blood protein measurement
1
1
1
42.6
serum albumin measurement
1
1
1
42.1
red blood cell density measurement
1
1
1
36
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
64
hemoglobin measurement
2
61.5
total blood protein measurement
1
42.6
serum albumin measurement
1
42.1
red blood cell density measurement
1
36
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase kinase 3
VGNC:300
459173
Macaque
mitogen-activated protein kinase kinase kinase kinase 3
713952
Mouse
MGI:2154405
225028
Rat
RGD:621280
170920
Dog
mitogen-activated protein kinase kinase kinase kinase 3
VGNC:42983
475734
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase kinase 3
Macaque
mitogen-activated protein kinase kinase kinase kinase 3
Mouse
Rat
Dog
mitogen-activated protein kinase kinase kinase kinase 3
Publication Statistics
PubMed Score 32.51
PubMed score by year
PubTator Score 22.94
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title