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Tbio
DNAH10
Dynein heavy chain 10, axonemal

Protein Summary
Description
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Probable inner arm dynein heavy chain. Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH10 is an inner arm dynein heavy chain (Maiti et al., 2000 [PubMed 11175280]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000638045
  • ENSP00000489675
  • ENSG00000197653

Symbol
  • KIAA2017
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.93
phenotype
0.77
cell type or tissue
0.7
histone modification site profile
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.66   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 15   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.66   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 15   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
9
3
16
99.4
appendicular lean mass
2
1
2
92.7
body fat percentage
1
1
1
85.5
body mass index
2
1
2
83.8
adiponectin measurement
1
1
1
77.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
16
99.4
appendicular lean mass
2
92.7
body fat percentage
1
85.5
body mass index
2
83.8
adiponectin measurement
1
77.8
Gene Ontology Terms (10)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (74)
1 – 10 of 74
DNAL4
Tbio
Novelty: 0.15546154
Score: 0.863
Data Source: STRINGDB
DYNLL1
Tbio
Novelty: 0.00397334
Score: 0.8
Data Source: STRINGDB
DYNLL2
Tbio
Novelty: 0.11209457
Score: 0.793
Data Source: STRINGDB
CFAP46
Tdark
Novelty: 0.73818628
Score: 0.775
Data Source: STRINGDB
DNAI2
Tbio
Novelty: 0.02801096
Score: 0.77
Data Source: STRINGDB
DNAH12
Tbio
Novelty: 0.02743114
Score: 0.763
Data Source: STRINGDB
DNAI1
Tbio
Novelty: 0.01021193
Score: 0.762
Data Source: STRINGDB
DYNC1LI1
Tbio
Novelty: 0.02164556
Score: 0.761
Data Source: STRINGDB
DYNC1LI2
Tbio
Novelty: 0.17381295
Score: 0.761
Data Source: STRINGDB
DCTN2
Tbio
Novelty: 0.01045432
Score: 0.758
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.66

PubMed score by year
PubTator Score  1.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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