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Tbio
AHNAK2
Protein AHNAK2

Protein Summary
Description
This gene encodes a large nucleoprotein. The encoded protein has a tripartite domain structure with a relatively short N-terminus and a long C-terminus, separated by a large body of repeats. The N-terminal PSD-95/Discs-large/ZO-1 (PDZ)-like domain is thought to function in the formation of stable homodimers. The encoded protein may play a role in calcium signaling by associating with calcium channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333244
  • ENSP00000353114
  • ENSG00000185567
  • ENST00000557457
  • ENSP00000450998

Symbol
  • C14orf78
  • KIAA2019
  • C14orf78
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
small molecule perturbation
0.75
kinase perturbation
0.71
transcription factor perturbation
0.68
interacting protein
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.77   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.77   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
AHNAK nucleoprotein 2
VGNC:12962
467570
Species
Name
OMA
EggNOG
Inparanoid
Chimp
AHNAK nucleoprotein 2
Protein Structure (1 Structure, 23 AlphaFold Models)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (10)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (37)
1 – 10 of 37
LMO2
Tbio
Novelty: 0.0038279
p_int: 0.999820473
p_ni: 0.000179527
Data Source: BioPlex
NUDT14
Tbio
Family: Enzyme
Novelty: 0.11929401
p_int: 0.999619773
p_ni: 0.000375645
p_wrong: 0.000004582
Score: 0.243
Data Source: BioPlex,STRINGDB
OMP
Tbio
Novelty: 0.00286211
p_int: 0.996101071
p_ni: 0.003787569
p_wrong: 0.00011136
Data Source: BioPlex
GLRX3
Tbio
Novelty: 0.0096265
p_int: 0.989550601
p_ni: 0.010449399
Data Source: BioPlex
GJB7
Tbio
Novelty: 0.12555147
p_int: 0.98936353
p_ni: 0.01063647
Data Source: BioPlex
PCK2
Tbio
Family: Kinase
Novelty: 0.0035563
p_int: 0.976010109
p_ni: 0.023989891
Data Source: BioPlex
PYCR2
Tbio
Family: Enzyme
Novelty: 0.05660996
p_int: 0.951811268
p_ni: 0.048188732
Score: 0.245
Data Source: BioPlex,STRINGDB
ANXA2
Tbio
Novelty: 0.00103362
p_int: 0.937156763
p_ni: 0.062843237
Score: 0.339
Data Source: BioPlex,STRINGDB
JSRP1
Tdark
Novelty: 0.08386808
p_int: 0.929800011
p_ni: 0.070199989
Score: 0.303
Data Source: BioPlex,STRINGDB
DUSP23
Tbio
Family: Enzyme
Novelty: 0.06522366
p_int: 0.92029128
p_ni: 0.079707015
p_wrong: 0.000001705
Score: 0.177
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  16.77

PubMed score by year
PubTator Score  5.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer