Protein Summary
This gene encodes a large nucleoprotein. The encoded protein has a tripartite domain structure with a relatively short N-terminus and a long C-terminus, separated by a large body of repeats. The N-terminal PSD-95/Discs-large/ZO-1 (PDZ)-like domain is thought to function in the formation of stable homodimers. The encoded protein may play a role in calcium signaling by associating with calcium channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
- ENST00000333244
- ENSP00000353114
- ENSG00000185567
- ENST00000557457
- ENSP00000450998
- C14orf78
- KIAA2019
- C14orf78
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
drug perturbation | 1 | ||
small molecule perturbation | 0.75 | ||
kinase perturbation | 0.71 | ||
transcription factor perturbation | 0.68 | ||
interacting protein | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.41 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 115 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.41 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 115 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (37)
NUDT14
Family: Enzyme
Novelty: 0.11929401
p_int: 0.999619773
p_ni: 0.000375645
p_wrong: 0.000004582
Score: 0.243
Data Source: BioPlex,STRINGDB
OMP
Novelty: 0.00286211
p_int: 0.996101071
p_ni: 0.003787569
p_wrong: 0.00011136
Data Source: BioPlex
PYCR2
Family: Enzyme
Novelty: 0.05660996
p_int: 0.951811268
p_ni: 0.048188732
Score: 0.245
Data Source: BioPlex,STRINGDB
ANXA2
Novelty: 0.00103362
p_int: 0.937156763
p_ni: 0.062843237
Score: 0.339
Data Source: BioPlex,STRINGDB
JSRP1
Novelty: 0.08386808
p_int: 0.929800011
p_ni: 0.070199989
Score: 0.303
Data Source: BioPlex,STRINGDB
DUSP23
Family: Enzyme
Novelty: 0.06522366
p_int: 0.92029128
p_ni: 0.079707015
p_wrong: 0.000001705
Score: 0.177
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (10)
Components (9)
Processes (1)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
2 | 2 | 0 | 1.2 | 67.1 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.2 | 67.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (1)
1 – 1 of 1
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | AHNAK nucleoprotein 2 | VGNC:12962 | 467570 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | AHNAK nucleoprotein 2 | |||||
Publication Statistics
PubMed Score 20.41
PubMed score by year
PubTator Score 5.52
PubTator score by year
Related Publications
Text Mined References (11)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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