Tbio AHNAK2 Protein AHNAK2

Protein Summary

Description

This gene encodes a large nucleoprotein. The encoded protein has a tripartite domain structure with a relatively short N-terminus and a long C-terminus, separated by a large body of repeats. The N-terminal PSD-95/Discs-large/ZO-1 (PDZ)-like domain is thought to function in the formation of stable homodimers. The encoded protein may play a role in calcium signaling by associating with calcium channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

Uniprot Accession IDs

• Q8IVF2
• Q5BKX7
• Q7Z343
• Q7Z358
• Q7Z394
• Q7Z3G0
• Q86WQ6
• Q8IYY1
• Q8N3G4
• Q96EX9

Gene Name

• AHNAK2

Ensembl ID

• ENST00000333244
• ENSP00000353114
• ENSG00000185567
• ENST00000557457
• ENSP00000450998

Symbol

• C14orf78
• KIAA2019
• C14orf78

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	1
small molecule perturbation	0.75
kinase perturbation	0.71
transcription factor perturbation	0.68
interacting protein	0.58

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.77   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 115   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.77   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (1)

1 – 1 of 1

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	AHNAK nucleoprotein 2	VGNC:12962	467570

Species	Name	OMA	EggNOG	Inparanoid
Chimp	AHNAK nucleoprotein 2

Protein Structure (1 Structure, 23 AlphaFold Models)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8IVF2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Gene Ontology Terms (10)

Components (9)

Processes (1)

Find Similar Targets

Items per page:

10

1 – 9 of 9

GO Term	Evidence	Assigned by
cytosol	Inferred from Direct Assay (IDA)	HPA
plasma membrane	Inferred from Direct Assay (IDA)	HPA
cytoplasm	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
T-tubule	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
costamere	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
cytoplasmic vesicle membrane	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
Z disc	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
sarcolemma	Non-traceable Author Statement (NAS)	UniProtKB
nucleus	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

Protein-Protein Interactions (37)

Explore Interacting Targets

1 – 10 of 37

• See Interactions on String-DB

LMO2

Tbio

Novelty: 0.0038279

p_int: 0.999820473

p_ni: 0.000179527

Data Source: BioPlex

NUDT14

Tbio

Family: Enzyme

Novelty: 0.11929401

p_int: 0.999619773

p_ni: 0.000375645

p_wrong: 0.000004582

Score: 0.243

Data Source: BioPlex,STRINGDB

OMP

Tbio

Novelty: 0.00286211

p_int: 0.996101071

p_ni: 0.003787569

p_wrong: 0.00011136

Data Source: BioPlex

GLRX3

Tbio

Novelty: 0.0096265

p_int: 0.989550601

p_ni: 0.010449399

Data Source: BioPlex

GJB7

Tbio

Novelty: 0.12555147

p_int: 0.98936353

p_ni: 0.01063647

Data Source: BioPlex

PCK2

Tbio

Family: Kinase

Novelty: 0.0035563

p_int: 0.976010109

p_ni: 0.023989891

Data Source: BioPlex

PYCR2

Tbio

Family: Enzyme

Novelty: 0.05660996

p_int: 0.951811268

p_ni: 0.048188732

Score: 0.245

Data Source: BioPlex,STRINGDB

ANXA2

Tbio

Novelty: 0.00103362

p_int: 0.937156763

p_ni: 0.062843237

Score: 0.339

Data Source: BioPlex,STRINGDB

JSRP1

Tdark

Novelty: 0.08386808

p_int: 0.929800011

p_ni: 0.070199989

Score: 0.303

Data Source: BioPlex,STRINGDB

DUSP23

Tbio

Family: Enzyme

Novelty: 0.06522366

p_int: 0.92029128

p_ni: 0.079707015

p_wrong: 0.000001705

Score: 0.177

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  16.77

PubMed score by year

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PubTator Score  5.52

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Acetylation
Alternative splicing
Complete proteome
Isopeptide bond
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Ubl conjugation