Protein Summary
This gene encodes a large nucleoprotein. The encoded protein has a tripartite domain structure with a relatively short N-terminus and a long C-terminus, separated by a large body of repeats. The N-terminal PSD-95/Discs-large/ZO-1 (PDZ)-like domain is thought to function in the formation of stable homodimers. The encoded protein may play a role in calcium signaling by associating with calcium channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
- ENST00000333244
- ENSP00000353114
- ENSG00000185567
- ENST00000557457
- ENSP00000450998
- C14orf78
- KIAA2019
- C14orf78
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 1 | ||
small molecule perturbation | 0.75 | ||
kinase perturbation | 0.71 | ||
transcription factor perturbation | 0.68 | ||
interacting protein | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.41 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 115 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.41 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 115 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (37)
NUDT14
Family: Enzyme
Novelty: 0.11929401
p_int: 0.999619773
p_ni: 0.000375645
p_wrong: 0.000004582
Score: 0.243
Data Source: BioPlex,STRINGDB
OMP
Novelty: 0.00286211
p_int: 0.996101071
p_ni: 0.003787569
p_wrong: 0.00011136
Data Source: BioPlex
PYCR2
Family: Enzyme
Novelty: 0.05660996
p_int: 0.951811268
p_ni: 0.048188732
Score: 0.245
Data Source: BioPlex,STRINGDB
ANXA2
Novelty: 0.00103362
p_int: 0.937156763
p_ni: 0.062843237
Score: 0.339
Data Source: BioPlex,STRINGDB
JSRP1
Novelty: 0.08386808
p_int: 0.929800011
p_ni: 0.070199989
Score: 0.303
Data Source: BioPlex,STRINGDB
DUSP23
Family: Enzyme
Novelty: 0.06522366
p_int: 0.92029128
p_ni: 0.079707015
p_wrong: 0.000001705
Score: 0.177
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (10)
Components (9)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
2 | 2 | 0 | 1.2 | 67.1 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.2 | 67.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (1)
1 – 1 of 1
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | AHNAK nucleoprotein 2 | VGNC:12962 | 467570 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | AHNAK nucleoprotein 2 | |||||
Publication Statistics
PubMed Score 20.41
PubMed score by year
PubTator Score 5.52
PubTator score by year
Related Publications
Text Mined References (11)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
|---|