You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SLC9A9
Sodium/hydrogen exchanger 9

Protein Summary
Description
May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell. This gene encodes a sodium/proton exchanger that is a member of the solute carrier 9 protein family. The encoded protein localizes the to the late recycling endosomes and may play an important role in maintaining cation homeostasis. Mutations in this gene are associated with autism susceptibility 16 and attention-deficit/hyperactivity disorder. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316549
  • ENSP00000320246
  • ENSG00000181804

Symbol
  • NHE9
  • NHE9
  • AUTS16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
transcription factor perturbation
0.8
molecular function
0.76
protein domain
0.73
phenotype
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.37   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 192   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.37   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 192   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
DOCK3
Tbio
Novelty:  0.02190804
Score:  0.811
Data Source:  STRINGDB
NPAS4
Tbio
Family:  TF
Novelty:  0.00942626
Score:  0.767
Data Source:  STRINGDB
SLC9A3R2
Tchem
Family:  Transporter
Novelty:  0.01401705
Score:  0.673
Data Source:  STRINGDB
C3orf58
Tbio
Novelty:  0.03694539
Score:  0.649
Data Source:  STRINGDB
C2CD2L
Tbio
Novelty:  0.2051681
Score:  0.615
Data Source:  STRINGDB
SLC9B2
Tbio
Family:  Transporter
Novelty:  0.04898001
Score:  0.601
Data Source:  STRINGDB
CDV3
Tbio
Novelty:  0.01946712
Score:  0.595
Data Source:  STRINGDB
KIAA1211
Tdark
Novelty:  0.83445472
Score:  0.593
Data Source:  STRINGDB
CHP1
Tbio
Novelty:  0.01299969
Score:  0.587
Data Source:  STRINGDB
EFR3A
Tbio
Novelty:  0.17687362
Score:  0.58
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Defective SLC9A9 causes autism 16 (AUTS16) (R-HSA-5619052)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective SLC9A9 causes autism 16 (AUTS16)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
SLC transporter disorders
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Defective SLC9A9 causes autism 16 (AUTS16)
Disease
Disorders of transmembrane transporters
SLC transporter disorders
SLC-mediated transmembrane transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
3
3
76
viral load
1
1
1
70.9
gut microbiome measurement
2
2
1
5.5
69.5
mean platelet volume
1
1
1
36.4
N-glycan measurement
1
1
1
31.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
3
76
viral load
1
70.9
gut microbiome measurement
1
5.5
69.5
mean platelet volume
1
36.4
N-glycan measurement
1
31.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 9 member A9
VGNC:8011
460751
Macaque
solute carrier family 9 member A9
713935
Mouse
MGI:2679732
331004
Rat
RGD:1560736
363115
Dog
solute carrier family 9 member A9
VGNC:46491
611417
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 9 member A9
Macaque
solute carrier family 9 member A9
Mouse
Rat
Dog
solute carrier family 9 member A9
Publication Statistics
PubMed Score 35.37
PubMed score by year
PubTator Score 21.59
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title