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Tbio
CNGA4
Cyclic nucleotide-gated cation channel alpha-4

Protein Summary
Description
Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity). CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001 [PubMed 11739959]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379936
  • ENSP00000369268
  • ENSG00000132259

Symbol
  • CNG4
  • CNG5
  • CNCA2
  • CNG-4
  • CNGB2
  • OCNC2
  • OCNCb
  • OCNCBETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
gene perturbation
0.76
protein domain
0.73
cell type or tissue
0.6
tissue sample
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.87   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.87   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (65)
1 – 10 of 65
CNGB1
Tbio
Family:  IC
Novelty:  0.01034916
Score:  0.945
Data Source:  Reactome,STRINGDB
PKD2
Tchem
Family:  IC
Novelty:  0.00305329
Score:  0.919
Data Source:  STRINGDB
RHO
Tbio
Family:  GPCR
Novelty:  0.00012925
Score:  0.913
Data Source:  STRINGDB
CNGA2
Tchem
Family:  IC
Novelty:  0.01050959
Score:  0.908
Data Source:  Reactome,STRINGDB
PKD1
Tbio
Novelty:  0.00288432
Score:  0.904
Data Source:  STRINGDB
EXOC3
Tbio
Novelty:  0.01051955
Score:  0.9
Data Source:  STRINGDB
EXOC2
Tbio
Novelty:  0.01434464
Score:  0.9
Data Source:  STRINGDB
RAB3IP
Tbio
Novelty:  0.04046982
Score:  0.9
Data Source:  Reactome,STRINGDB
ASAP1
Tbio
Novelty:  0.00913771
Score:  0.9
Data Source:  Reactome,STRINGDB
EXOC7
Tbio
Novelty:  0.00852508
Score:  0.9
Data Source:  STRINGDB
Pathways (7)
Cargo trafficking to the periciliary membrane (R-HSA-5620920)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Reactome
VxPx cargo-targeting to cilium
Name
Explore in Pharos
Explore in Source
Cargo trafficking to the periciliary membrane
Cilium Assembly
Organelle biogenesis and maintenance
VxPx cargo-targeting to cilium
Gene Ontology Terms (10)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
38.8
body mass index
1
1
1
29
mathematical ability
3
1
3
9.5
1
1
0
1
3.5
multisite chronic pain
1
1
1
2.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
38.8
body mass index
1
29
mathematical ability
3
9.5
0
1
3.5
multisite chronic pain
1
2.5
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclic nucleotide gated channel alpha 4
VGNC:3149
466413
Mouse
MGI:2664099
233649
Rat
RGD:619844
85258
Dog
cyclic nucleotide gated channel alpha 4
VGNC:39397
476830
Cow
cyclic nucleotide gated channel alpha 4
VGNC:27500
516000
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclic nucleotide gated channel alpha 4
Mouse
Rat
Dog
cyclic nucleotide gated channel alpha 4
Cow
cyclic nucleotide gated channel alpha 4
Publication Statistics
PubMed Score 14.87
PubMed score by year
PubTator Score 7.59
PubTator score by year
Patents
Patents by year