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Tchem
RASGRP3
Ras guanyl-releasing protein 3

Protein Summary
Description
Guanine nucleotide exchange factor (GEF) for Ras and Rap1. The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000402538
  • ENSP00000385886
  • ENSG00000152689
  • ENST00000403687
  • ENSP00000384192
  • ENST00000407811
  • ENSP00000383917

Symbol
  • GRP3
  • KIAA0846
  • GRP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
protein domain
0.99
molecular function
0.81
kinase perturbation
0.76
transcription factor
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.73   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.73   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 77
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (83)
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.954
Data Source:  Reactome,STRINGDB
RRAS
Tbio
Family:  Enzyme
Novelty:  0.00786502
Score:  0.953
Data Source:  STRINGDB
KRAS
Tclin
Family:  Enzyme
Novelty:  0.00013856
Score:  0.943
Data Source:  Reactome,STRINGDB
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
Score:  0.937
Data Source:  Reactome,STRINGDB
RAP1A
Tchem
Family:  Enzyme
Novelty:  0.00375413
Score:  0.922
Data Source:  STRINGDB
RASGRP1
Tchem
Novelty:  0.00776879
Score:  0.906
Data Source:  STRINGDB
RAP1B
Tbio
Family:  Enzyme
Novelty:  0.00627538
Score:  0.888
Data Source:  STRINGDB
PLCG2
Tchem
Family:  Enzyme
Novelty:  0.00294726
Score:  0.879
Data Source:  STRINGDB
SOS1
Tchem
Novelty:  0.00285343
Score:  0.847
Data Source:  STRINGDB
SOS2
Tbio
Novelty:  0.01607832
Score:  0.843
Data Source:  STRINGDB
Nearest Tclin Targets (13)
Explore Nearest Tclin Targets
1 – 5 of 9
CACNA1S
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
CACNA1B
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
CACNA1D
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
CACNA1H
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
CACNA1C
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
Pathways (25)
Activation of RAS in B cells (R-HSA-1169092)

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Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of RAS in B cells
Reactome
Adaptive Immune System
Reactome
Cytokine Signaling in Immune system
Reactome
Downstream signaling events of B Cell Receptor (BCR)
Reactome
FLT3 Signaling
Name
Explore in Pharos
Explore in Source
Activation of RAS in B cells
Adaptive Immune System
Cytokine Signaling in Immune system
Downstream signaling events of B Cell Receptor (BCR)
FLT3 Signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.4
64.9
serum non-albumin protein measurement
1
1
1
62.6
albumin:globulin ratio measurement
1
1
1
52.4
BMI-adjusted hip circumference
1
1
1
29
BMI-adjusted waist circumference
1
1
1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
64.9
serum non-albumin protein measurement
1
62.6
albumin:globulin ratio measurement
1
52.4
BMI-adjusted hip circumference
1
29
BMI-adjusted waist circumference
1
26.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAS guanyl releasing protein 3
VGNC:7701
470348
Mouse
MGI:3028579
240168
Rat
RGD:1304612
313874
Dog
RAS guanyl releasing protein 3
VGNC:45373
611329
Horse
RAS guanyl releasing protein 3
VGNC:22203
100070505
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAS guanyl releasing protein 3
Mouse
Rat
Dog
RAS guanyl releasing protein 3
Horse
RAS guanyl releasing protein 3
Publication Statistics
PubMed Score 57.73
PubMed score by year
PubTator Score 29.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title