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Tchem
RASGRP3
Ras guanyl-releasing protein 3

Protein Summary
Description
Guanine nucleotide exchange factor (GEF) for Ras and Rap1. The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000402538
  • ENSP00000385886
  • ENSG00000152689
  • ENST00000403687
  • ENSP00000384192
  • ENST00000407811
  • ENSP00000383917

Symbol
  • GRP3
  • KIAA0846
  • GRP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
protein domain
0.99
molecular function
0.81
kinase perturbation
0.76
transcription factor
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.7   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.7   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 77
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0