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Tchem
RASGRP3
Ras guanyl-releasing protein 3

Protein Summary
Description
Guanine nucleotide exchange factor (GEF) for Ras and Rap1. The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000402538
  • ENSP00000385886
  • ENSG00000152689
  • ENST00000403687
  • ENSP00000384192
  • ENST00000407811
  • ENSP00000383917

Symbol
  • GRP3
  • KIAA0846
  • GRP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
protein domain
0.99
molecular function
0.81
kinase perturbation
0.76
transcription factor
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.72   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.72   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 44
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.4
78.9
serum non-albumin protein measurement
1
1
1
38.5
albumin:globulin ratio measurement
1
1
1
29.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
78.9
serum non-albumin protein measurement
1
38.5
albumin:globulin ratio measurement
1
29.2
Pathways (25)
Activation of RAS in B cells (R-HSA-1169092)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of RAS in B cells
Reactome
Adaptive Immune System
Reactome
Cytokine Signaling in Immune system
Reactome
Downstream signaling events of B Cell Receptor (BCR)
Reactome
FLT3 Signaling
Name
Explore in Pharos
Explore in Source
Activation of RAS in B cells
Adaptive Immune System
Cytokine Signaling in Immune system
Downstream signaling events of B Cell Receptor (BCR)
FLT3 Signaling
Gene Ontology Terms (13)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (83)
1 – 10 of 83
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
Score: 0.954
Data Source: Reactome,STRINGDB
RRAS
Tbio
Family: Enzyme
Novelty: 0.00786502
Score: 0.953
Data Source: STRINGDB
KRAS
Tchem
Family: Enzyme
Novelty: 0.00013856
Score: 0.943
Data Source: Reactome,STRINGDB
NRAS
Tchem
Family: Enzyme
Novelty: 0.00080922
Score: 0.937
Data Source: Reactome,STRINGDB
RAP1A
Tchem
Family: Enzyme
Novelty: 0.00375413
Score: 0.922
Data Source: STRINGDB
RASGRP1
Tchem
Novelty: 0.00776879
Score: 0.906
Data Source: STRINGDB
RAP1B
Tbio
Family: Enzyme
Novelty: 0.00627538
Score: 0.888
Data Source: STRINGDB
PLCG2
Tchem
Family: Enzyme
Novelty: 0.00294726
Score: 0.879
Data Source: STRINGDB
SOS1
Tbio
Novelty: 0.00285343
Score: 0.847
Data Source: STRINGDB
SOS2
Tbio
Novelty: 0.01607832
Score: 0.843
Data Source: STRINGDB
Publication Statistics
PubMed Score  57.72

PubMed score by year
PubTator Score  29.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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