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Tbio
ERI1
3'-5' exoribonuclease 1

Protein Summary
Description
RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250263
  • ENSP00000250263
  • ENSG00000104626
  • ENST00000519292
  • ENSP00000430190
  • ENST00000523898
  • ENSP00000429615

Symbol
  • 3'EXO
  • THEX1
  • HEXO
  • THEX1
  • 3'HEXO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
transcription factor binding site profile
0.83
virus perturbation
0.83
kinase perturbation
0.81
interacting protein
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.71   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.71   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (123)
MAGEA10
Tbio
Novelty:  0.05364393
p_int:  0.999997942
p_ni:  2e-9
p_wrong:  0.000002056
Score:  0.209
Data Source:  BioPlex,STRINGDB
SLBP
Tbio
Novelty:  0.00685735
Score:  0.998
Data Source:  STRINGDB
PELP1
Tbio
Novelty:  0.00817675
Score:  0.95
Data Source:  STRINGDB
RPL38
Tbio
Novelty:  0.02694553
Score:  0.935
Data Source:  STRINGDB
DICER1
Tbio
Family:  Enzyme
Novelty:  0.000306
Score:  0.92
Data Source:  STRINGDB
SENP3
Tbio
Family:  Enzyme
Novelty:  0.00374663
Score:  0.907
Data Source:  STRINGDB
RPL26
Tbio
Novelty:  0.02077198
Score:  0.903
Data Source:  STRINGDB
RPL19
Tbio
Novelty:  0.00756385
Score:  0.902
Data Source:  STRINGDB
RPL8
Tbio
Novelty:  0.01064076
Score:  0.902
Data Source:  STRINGDB
RPL10
Tbio
Novelty:  0.01299391
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (35)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
2
23
23
96.6
reticulocyte count
6
7
10
93.6
reticulocyte measurement
3
5
5
92
BMI-adjusted waist circumference
2
35
37
87.2
alkaline phosphatase measurement
1
1
1
85.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
23
96.6
reticulocyte count
10
93.6
reticulocyte measurement
5
92
BMI-adjusted waist circumference
37
87.2
alkaline phosphatase measurement
1
85.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
exoribonuclease 1
699381
Mouse
MGI:1914526
67276
Rat
RGD:1308378
361159
Dog
exoribonuclease 1
VGNC:40454
482882
Horse
exoribonuclease 1
VGNC:17664
100147421
Species
Name
OMA
EggNOG
Inparanoid
Macaque
exoribonuclease 1
Mouse
Rat
Dog
exoribonuclease 1
Horse
exoribonuclease 1
Publication Statistics
PubMed Score 110.71
PubMed score by year
PubTator Score 21.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title