You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
WDR49
WD repeat-containing protein 49

Protein Summary
Description
This gene encodes a member of the WD repeat protein family with nine WD repeats. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308378
  • ENSP00000311343
  • ENSG00000174776
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.97
cellular component
0.75
protein domain
0.73
cell line
0.69
tissue sample
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (19)
1 – 10 of 19
ARHGAP17
Tbio
Family: Enzyme
Novelty: 0.01399656
p_int: 0.99991815
p_ni: 0.00008185
p_wrong: 1e-9
Score: 0.517
Data Source: BioPlex,STRINGDB
ZBBX
Tdark
Novelty: 5.95833333
Score: 0.74
Data Source: STRINGDB
BBS10
Tbio
Novelty: 0.04807564
Score: 0.733
Data Source: STRINGDB
NRSN2
Tbio
Novelty: 0.30769231
Score: 0.667
Data Source: STRINGDB
GJD4
Tdark
Novelty: 0.63138347
Score: 0.632
Data Source: STRINGDB
WDR37
Tdark
Novelty: 0.53023256
Score: 0.598
Data Source: STRINGDB
FSTL5
Tbio
Novelty: 0.14507772
Score: 0.588
Data Source: STRINGDB
ARMCX2
Tdark
Novelty: 0.26022305
Score: 0.583
Data Source: STRINGDB
ARMCX1
Tbio
Novelty: 0.10359186
Score: 0.578
Data Source: STRINGDB
XPO4
Tbio
Novelty: 0.02272837
Score: 0.509
Data Source: STRINGDB
Publication Statistics
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer