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Tbio
LACC1
Laccase domain-containing protein 1

Protein Summary
Description
Central regulator of the metabolic function and bioenergetic state of macrophages. In macrophages, promotes flux through de novo lipogenesis to concomitantly drive high levels of both fatty-acid oxidation and glycolysis. This gene encodes an oxidoreductase that promotes fatty-acid oxidation, with concomitant inflammasome activation, mitochondrial and NADPH-oxidase-dependent reactive oxygen species production, and bactericidal activity of macrophages. The encoded protein forms a complex with fatty acid synthase on peroxisomes and is thought to be modulated by peroxisome proliferator-activated receptor signaling events. Naturally occurring mutations in this gene are associated with inflammatory bowel disease, Behcet's disease, leprosy, ulcerative colitis, early-onset Crohn's disease, and systemic juvenile idiopathic arthritis. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325686
  • ENSP00000317619
  • ENSG00000179630
  • ENST00000441843
  • ENSP00000391747

Symbol
  • C13orf31
  • FAMIN
  • FAMIN
  • C13orf31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
phenotype
0.7
trait
0.61
tissue sample
0.56
disease
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.94   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.94   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (108)
OSER1
Tdark
Novelty:  0.21052793
p_int:  0.999999999
p_ni:  1e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
H3F3A
Tbio
Novelty:  0.00508186
p_int:  0.999999933
p_ni:  6.6e-8
p_wrong:  1e-9
Data Source:  BioPlex
HIST2H2AC
Tbio
Novelty:  0.00065524
p_int:  0.999986397
p_ni:  0.000013602
p_wrong:  1e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
TPT1
Tbio
Novelty:  0.00212091
p_int:  0.9995299
p_ni:  0.0004701
Data Source:  BioPlex
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
p_int:  0.999362472
p_ni:  0.000593539
p_wrong:  0.000043988
Data Source:  BioPlex
DNAJB2
Tbio
Novelty:  0.046216
p_int:  0.999227168
p_ni:  0.000765463
p_wrong:  0.000007369
Score:  0.154
Data Source:  BioPlex,STRINGDB
PALM2
Tbio
Novelty:  0.03469098
p_int:  0.998932379
p_ni:  0.001053703
p_wrong:  0.000013918
Data Source:  BioPlex
TSNAX
Tbio
Novelty:  0.00888891
p_int:  0.997630845
p_ni:  0.002369155
Data Source:  BioPlex
ATP6V1G1
Tbio
Family:  Enzyme
Novelty:  0.07710789
p_int:  0.997257219
p_ni:  0.002727455
p_wrong:  0.000015326
Data Source:  BioPlex
DUSP14
Tbio
Family:  Enzyme
Novelty:  0.04013065
p_int:  0.995874137
p_ni:  0.004125863
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.6
89.5
3
1
0
1.2
73.9
1
1
0
1.1
65.3
1
1
0
1
27.3
intelligence
1
1
1
1.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
89.5
0
1.2
73.9
0
1.1
65.3
0
1
27.3
intelligence
1
1.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
laccase domain containing 1
VGNC:7309
452569
Macaque
laccase domain containing 1
700834
Mouse
MGI:2445077
210808
Rat
RGD:1310185
313790
Dog
laccase domain containing 1
476928
Species
Name
OMA
EggNOG
Inparanoid
Chimp
laccase domain containing 1
Macaque
laccase domain containing 1
Mouse
Rat
Dog
laccase domain containing 1
Publication Statistics
PubMed Score 33.94
PubMed score by year
PubTator Score 10.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title