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Tbio
GPIHBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Protein Summary
Description
Plays a key role in the lipolytic processing of chylomicrons. Required for the transport of lipoprotein lipase LPL into the capillary lumen (By similarity). This gene encodes a capillary endothelial cell protein that facilitates the lipolytic processing of triglyceride-rich lipoproteins. The encoded protein is a glycosylphosphatidylinositol-anchored protein that is a member of the lymphocyte antigen 6 (Ly6) family. This protein plays a major role in transporting lipoprotein lipase (LPL) from the subendothelial spaces to the capillary lumen. Mutations in this gene are the cause of hyperlipoproteinemia, type 1D. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000622500
  • ENSP00000480053
  • ENSG00000277494

Symbol
  • HBP1
  • HYPL1D
  • GPI-HBP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.63
cellular component
0.62
cell type or tissue
0.59
biological process
0.55
tissue sample
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.12   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.12   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (145)
NDUFA12
Tclin
Family:  Enzyme
Novelty:  0.04679316
p_int:  0.999955221
p_ni:  0.000016789
p_wrong:  0.00002799
Data Source:  BioPlex
PPY
Tbio
Novelty:  0.00060933
p_int:  0.998149896
p_ni:  0.001654142
p_wrong:  0.000195962
Data Source:  BioPlex
UBE2L6
Tbio
Novelty:  0.03471633
p_int:  0.996830348
p_ni:  0.001803063
p_wrong:  0.001366589
Data Source:  BioPlex
RFESD
Tdark
Novelty:  1.19159347
p_int:  0.977766525
p_ni:  0.001109381
p_wrong:  0.021124094
Data Source:  BioPlex
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
p_int:  0.947512872
p_ni:  0.00404445
p_wrong:  0.048442677
Data Source:  BioPlex
IL1RN
Tchem
Novelty:  0.00070533
p_int:  0.776982318
p_ni:  0.004501448
p_wrong:  0.218516234
Data Source:  BioPlex
LPL
Tchem
Family:  Enzyme
Novelty:  0.00057058
Score:  0.993
Data Source:  Reactome,STRINGDB
APOA5
Tbio
Novelty:  0.00232222
Score:  0.988
Data Source:  STRINGDB
LY6H
Tbio
Novelty:  0.10210816
Score:  0.979
Data Source:  STRINGDB
APOC2
Tbio
Novelty:  0.0015496
Score:  0.978
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Assembly of active LPL and LIPC lipase complexes (R-HSA-8963889)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of active LPL and LIPC lipase complexes
Reactome
Chylomicron remodeling
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Assembly of active LPL and LIPC lipase complexes
Chylomicron remodeling
G alpha (i) signalling events
GPCR downstream signalling
Metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
6
5
7
96.4
apolipoprotein A 1 measurement
2
3
3
92.9
BMI-adjusted hip circumference
1
3
3
45.2
mathematical ability
2
1
2
30.2
triglyceride measurement
1
1
1
4.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
7
96.4
apolipoprotein A 1 measurement
3
92.9
BMI-adjusted hip circumference
3
45.2
mathematical ability
2
30.2
triglyceride measurement
1
4.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1915703
68453
Rat
RGD:1564237
300027
Dog
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
VGNC:41382
609267
Horse
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
VGNC:18495
100066111
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
Horse
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
Publication Statistics
PubMed Score 118.12
PubMed score by year
PubTator Score 50.62
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title