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Tbio
PLD3
Phospholipase D3

Protein Summary
Description
May be involved in APP processing. This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356508
  • ENSP00000348901
  • ENSG00000105223
  • ENST00000409281
  • ENSP00000387022
  • ENST00000409419
  • ENSP00000386293
  • ENST00000409587
  • ENSP00000387050
  • ENST00000409735
  • ENSP00000386938

Symbol
  • AD19
  • HUK4
  • HU-K4
  • SCA46
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.96
histone modification site profile
0.87
transcription factor perturbation
0.84
disease perturbation
0.79
small molecule perturbation
0.7


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.42   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.42   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase D family member 3
VGNC:13309
468882
Macaque
phospholipase D family member 3
701083
Mouse
MGI:1333782
18807
Rat
RGD:1308248
361527
Dog
phospholipase D family member 3
VGNC:44662
484502
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase D family member 3
Macaque
phospholipase D family member 3
Mouse
Rat
Dog
phospholipase D family member 3
Pathways (14)
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Glycerophospholipid biosynthesis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis
Glycerophospholipid biosynthesis
Immune System
Innate Immune System
Metabolism
Protein-Protein Interactions (108)
1 – 10 of 108
LSMEM2
Tdark
Novelty: 43
p_int: 0.989712457
p_ni: 0.010287543
Data Source: BioPlex
PLD2
Tchem
Family: Enzyme
Novelty: 0.00331129
Score: 0.914
Data Source: STRINGDB
CHPT1
Tbio
Family: Enzyme
Novelty: 0.02875977
Score: 0.91
Data Source: STRINGDB
PEMT
Tbio
Family: Enzyme
Novelty: 0.00786252
Score: 0.909
Data Source: STRINGDB
HIPK4
Tchem
Family: Kinase
Novelty: 0.28272299
Score: 0.908
Data Source: STRINGDB
LCAT
Tbio
Family: Enzyme
Novelty: 0.00307544
Score: 0.903
Data Source: STRINGDB
PISD
Tbio
Family: Enzyme
Novelty: 0.00966227
Score: 0.903
Data Source: STRINGDB
CDS2
Tbio
Family: Enzyme
Novelty: 0.13210626
Score: 0.902
Data Source: STRINGDB
PLPP4
Tbio
Family: Enzyme
Novelty: 0.22418589
Score: 0.902
Data Source: STRINGDB
LPCAT4
Tdark
Family: Enzyme
Novelty: 0.246654
Score: 0.902
Data Source: STRINGDB
Publication Statistics
PubMed Score  68.42

PubMed score by year
PubTator Score  31.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer