Protein Summary
May be involved in APP processing. This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2014]
- ENST00000356508
- ENSP00000348901
- ENSG00000105223
- ENST00000409281
- ENSP00000387022
- ENST00000409419
- ENSP00000386293
- ENST00000409587
- ENSP00000387050
- ENST00000409735
- ENSP00000386938
- AD19
- HUK4
- HU-K4
- SCA46
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
metabolite | 0.96 | ||
histone modification site profile | 0.87 | ||
transcription factor perturbation | 0.84 | ||
disease perturbation | 0.79 | ||
small molecule perturbation | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 101.1 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 127 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 101.1 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 127 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0