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Tbio
TBC1D10C
Carabin

Protein Summary
Description
Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras. The protein encoded by this gene has an N-terminal Rab-GTPase domain and a binding site at the C-terminus for calcineurin, and is an inhibitor of both the Ras signaling pathway and calcineurin, a phosphatase regulated by calcium and calmodulin. Genes encoding similar proteins are located on chromosomes 16 and 22. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312390
  • ENSP00000310193
  • ENSG00000175463
  • ENST00000526387
  • ENSP00000435543
  • ENST00000542590
  • ENSP00000443654

Symbol
  • EPI64C
  • CARABIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.78
biological process
0.72
cell line
0.68
tissue sample
0.65
kinase perturbation
0.48


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.09   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.09   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
3
3
94.9
body height
2
2
2
94.5
mean corpuscular volume
2
3
3
94
mean corpuscular hemoglobin concentration
2
2
2
89
IGF-1 measurement
1
2
2
65.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
3
94.9
body height
2
94.5
mean corpuscular volume
3
94
mean corpuscular hemoglobin concentration
2
89
IGF-1 measurement
2
65.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 10C
VGNC:3043
451367
Macaque
TBC1 domain family member 10C
712270
Mouse
MGI:1922072
108995
Rat
RGD:1311490
361697
Dog
TBC1 domain family member 10C
VGNC:47130
610509
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 10C
Macaque
TBC1 domain family member 10C
Mouse
Rat
Dog
TBC1 domain family member 10C
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IV04-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Membrane Trafficking
Reactome
Neutrophil degranulation
Reactome
Rab regulation of trafficking
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Membrane Trafficking
Neutrophil degranulation
Rab regulation of trafficking
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (23)
1 – 10 of 23
RAB35
Tbio
Family:  Enzyme
Novelty:  0.01514601
Score:  0.973
Data Source:  STRINGDB
DENND1C
Tbio
Novelty:  0.82231203
Score:  0.536
Data Source:  STRINGDB
RUSC2
Tbio
Novelty:  0.14691927
Score:  0.528
Data Source:  STRINGDB
TBC1D21
Tdark
Novelty:  0.45203791
Score:  0.524
Data Source:  STRINGDB
TBC1D13
Tdark
Novelty:  0.60353273
Score:  0.518
Data Source:  STRINGDB
TBC1D22B
Tbio
Novelty:  0.49852962
Score:  0.517
Data Source:  STRINGDB
TBC1D22A
Tbio
Novelty:  0.46374046
Score:  0.512
Data Source:  STRINGDB
HAL
Tbio
Family:  Enzyme
Novelty:  0.01504631
Score:  0.506
Data Source:  STRINGDB
TBC1D19
Tdark
Novelty:  1.33062726
Score:  0.501
Data Source:  STRINGDB
CDC16
Tbio
Novelty:  0.00916715
Score:  0.487
Data Source:  STRINGDB
Publication Statistics
PubMed Score  7.09

PubMed score by year
PubTator Score  8.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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