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Tbio
AEBP1
Adipocyte enhancer-binding protein 1

Protein Summary
Description
Isoform 1: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellualr matrix. Isoform 2: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223357
  • ENSP00000223357
  • ENSG00000106624
  • ENST00000450684
  • ENSP00000398878

Symbol
  • ACLP
  • ACLP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
PubMedID
0.77
tissue sample
0.74
protein domain
0.73
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.47   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.47   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
TCF3
Tbio
Family:  TF
Novelty:  0.00112675
Score:  0.707
Data Source:  STRINGDB
AGTPBP1
Tbio
Family:  Enzyme
Novelty:  0.01925456
Score:  0.691
Data Source:  STRINGDB
CPA6
Tbio
Family:  Enzyme
Novelty:  0.05034597
Score:  0.679
Data Source:  STRINGDB
SYS1
Tbio
Novelty:  0.03311919
Score:  0.67
Data Source:  STRINGDB
CPB1
Tchem
Family:  Enzyme
Novelty:  0.00108031
Score:  0.643
Data Source:  STRINGDB
TP53TG5
Tdark
Novelty:  0.85042329
Score:  0.634
Data Source:  STRINGDB
MYL7
Tbio
Novelty:  0.00899028
Score:  0.592
Data Source:  STRINGDB
THBS2
Tbio
Novelty:  0.00310724
Score:  0.585
Data Source:  STRINGDB
ASPA
Tbio
Family:  Enzyme
Novelty:  0.02701619
Score:  0.576
Data Source:  STRINGDB
LRRTM4
Tbio
Novelty:  0.07741851
Score:  0.563
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
12
14
22
99.8
glucose measurement
6
11
12
99.8
fasting blood glucose measurement
12
6
17
98.9
8
6
8
1.1
94.7
birth weight
4
2
5
93.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
22
99.8
glucose measurement
12
99.8
fasting blood glucose measurement
17
98.9
8
1.1
94.7
birth weight
5
93.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
AE binding protein 1
VGNC:13625
463922
Macaque
AE binding protein 1
699977
Mouse
MGI:1197012
11568
Rat
RGD:1306922
305494
Dog
AE binding protein 1
VGNC:37681
608927
Species
Name
OMA
EggNOG
Inparanoid
Chimp
AE binding protein 1
Macaque
AE binding protein 1
Mouse
Rat
Dog
AE binding protein 1
Publication Statistics
PubMed Score 75.47
PubMed score by year
PubTator Score 24.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title