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Tbio
ARMC8
Armadillo repeat-containing protein 8

Protein Summary
Description
Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358441
  • ENSP00000351221
  • ENSG00000114098
  • ENST00000461822
  • ENSP00000420706
  • ENST00000469044
  • ENSP00000419413
  • ENST00000471453
  • ENSP00000420440
  • ENST00000481646
  • ENSP00000420333
  • ENST00000491704
  • ENSP00000417304
  • ENST00000538260
  • ENSP00000441592

Symbol
  • GID5
  • VID28
  • S863-2
  • HSPC056
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.86
transcription factor perturbation
0.84
histone modification site profile
0.73
transcription factor binding site profile
0.71
tissue sample
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.3   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.3   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (196)
GCG
Tchem
Novelty:  0.00004879
p_int:  0.999828277
p_ni:  0.000171723
Data Source:  BioPlex
TIGD5
Tdark
Novelty:  1.93340494
p_int:  0.998336953
p_ni:  0.001663047
Data Source:  BioPlex
BMP1
Tchem
Novelty:  0.00299518
p_int:  0.997533221
p_ni:  0.002466779
Data Source:  BioPlex
RMND5A
Tbio
Novelty:  0.01820349
p_int:  0.997470001
p_ni:  0.002529999
Score:  0.964
Data Source:  BioPlex,STRINGDB
PRG3
Tbio
Novelty:  0.09431986
p_int:  0.996973131
p_ni:  0.003026869
Score:  0.908
Data Source:  BioPlex,STRINGDB
PIGT
Tbio
Family:  Enzyme
Novelty:  0.02539879
p_int:  0.996393025
p_ni:  0.003606975
Data Source:  BioPlex
PRICKLE3
Tbio
Novelty:  0.26347141
p_int:  0.995400887
p_ni:  0.004599113
Data Source:  BioPlex
TDGF1
Tbio
Novelty:  0.00527099
p_int:  0.994210067
p_ni:  0.005789933
Score:  0.303
Data Source:  BioPlex,STRINGDB
PRG2
Tbio
Novelty:  0.00548995
p_int:  0.992745496
p_ni:  0.007254504
Data Source:  BioPlex
CCDC120
Tbio
Novelty:  0.48574876
p_int:  0.986268172
p_ni:  0.013731828
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
3
3
1.1
88.7
BMI-adjusted waist-hip ratio
2
3
3
80.7
testosterone measurement
3
2
3
75.7
body mass index
3
3
4
70.9
mathematical ability
3
3
5
60.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
88.7
BMI-adjusted waist-hip ratio
3
80.7
testosterone measurement
3
75.7
body mass index
4
70.9
mathematical ability
5
60.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
armadillo repeat containing 8
716388
Mouse
MGI:1921375
74125
Rat
RGD:1310477
315949
Dog
armadillo repeat containing 8
VGNC:38128
485684
Horse
armadillo repeat containing 8
VGNC:15533
100066776
Species
Name
OMA
EggNOG
Inparanoid
Macaque
armadillo repeat containing 8
Mouse
Rat
Dog
armadillo repeat containing 8
Horse
armadillo repeat containing 8
Publication Statistics
PubMed Score 19.30
PubMed score by year
PubTator Score 10.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title