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Tbio
CREBRF
CREB3 regulatory factor

Protein Summary
Description
Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296953
  • ENSP00000296953
  • ENSG00000164463
  • ENST00000520420
  • ENSP00000428290
  • ENST00000522692
  • ENSP00000431107

Symbol
  • C5orf41
  • LRF
  • C5orf41
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.92
kinase perturbation
0.81
transcription factor binding site profile
0.77
transcription factor
0.73
tissue sample
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.01   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.01   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (14)
ATF1
Tchem
Family:  TF
Novelty:  0.01450941
p_int:  0.991540207
p_ni:  0.00845898
p_wrong:  8.13e-7
Score:  0.39
Data Source:  BioPlex,STRINGDB
CREB3
Tbio
Family:  TF
Novelty:  0.00424318
Score:  0.97
Data Source:  Reactome,STRINGDB
CREBL2
Tdark
Family:  TF
Novelty:  0.19415056
Score:  0.764
Data Source:  STRINGDB
ATP6V0E1
Tbio
Family:  Enzyme
Novelty:  0.076209
Score:  0.729
Data Source:  STRINGDB
BNIP1
Tbio
Novelty:  0.04601895
Score:  0.656
Data Source:  STRINGDB
TRIB2
Tbio
Family:  Kinase
Novelty:  0.02240668
Score:  0.638
Data Source:  STRINGDB
CREB3L4
Tbio
Family:  TF
Novelty:  0.02532901
Score:  0.571
Data Source:  STRINGDB
KLHL24
Tbio
Novelty:  0.04032749
Score:  0.554
Data Source:  STRINGDB
ERGIC1
Tbio
Novelty:  0.15892956
Score:  0.547
Data Source:  STRINGDB
MAGEB16
Tdark
Novelty:  0.4467116
Score:  0.505
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
CREB3 factors activate genes (R-HSA-8874211)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
CREB3 factors activate genes
Reactome
Metabolism of proteins
Reactome
Unfolded Protein Response (UPR)
Name
Explore in Pharos
Explore in Source
CREB3 factors activate genes
Metabolism of proteins
Unfolded Protein Response (UPR)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.4
81.7
smoking status measurement
1
1
1
80.2
PR interval
2
2
0
1.4
60.4
self reported educational attainment
1
1
1
21.5
electrocardiography
1
1
15
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
81.7
smoking status measurement
1
80.2
PR interval
0
1.4
60.4
self reported educational attainment
1
21.5
electrocardiography
15
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CREB3 regulatory factor
VGNC:11892
462272
Macaque
CREB3 regulatory factor
703459
Mouse
MGI:1924378
77128
Rat
RGD:1310862
303016
Dog
CREB3 regulatory factor
VGNC:39603
612888
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CREB3 regulatory factor
Macaque
CREB3 regulatory factor
Mouse
Rat
Dog
CREB3 regulatory factor
Publication Statistics
PubMed Score 30.01
PubMed score by year
PubTator Score 201.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title