CREBRF
CREB3 regulatory factor
Protein Summary
Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci.
- ENST00000296953
- ENSP00000296953
- ENSG00000164463
- ENST00000520420
- ENSP00000428290
- ENST00000522692
- ENSP00000431107
- C5orf41
- LRF
- C5orf41
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
microRNA | 0.92 | ||
kinase perturbation | 0.81 | ||
transcription factor binding site profile | 0.77 | ||
transcription factor | 0.73 | ||
tissue sample | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30.01 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 26 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30.01 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 26 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
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Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (14)
ATF1
Family: TF
Novelty: 0.01450941
p_int: 0.991540207
p_ni: 0.00845898
p_wrong: 8.13e-7
Score: 0.39
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | CREB3 factors activate genes | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Unfolded Protein Response (UPR) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
CREB3 factors activate genes | ||||
Metabolism of proteins | ||||
Unfolded Protein Response (UPR) | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (3)
Components (4)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Sequence Model (ISM) | NTNU_SB | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
3 | 2 | 0 | 1.4 | 81.7 | |||||
smoking status measurement | 1 | 1 | 1 | 80.2 | |||||
PR interval | 2 | 2 | 0 | 1.4 | 60.4 | ||||
self reported educational attainment | 1 | 1 | 1 | 21.5 | |||||
electrocardiography | 1 | 1 | 15 | 21.5 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.4 | 81.7 | |||||
smoking status measurement | 1 | 80.2 | |||||
PR interval | 0 | 1.4 | 60.4 | ||||
self reported educational attainment | 1 | 21.5 | |||||
electrocardiography | 15 | 21.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | CREB3 regulatory factor | VGNC:11892 | 462272 | |||||
Macaque | CREB3 regulatory factor | 703459 | ||||||
Mouse | MGI:1924378 | 77128 | ||||||
Rat | RGD:1310862 | 303016 | ||||||
Dog | CREB3 regulatory factor | VGNC:39603 | 612888 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | CREB3 regulatory factor | |||||
Macaque | CREB3 regulatory factor | |||||
Mouse | ||||||
Rat | ||||||
Dog | CREB3 regulatory factor | |||||
Publication Statistics
PubMed Score 30.01
PubMed score by year
PubTator Score 201.33
PubTator score by year
Related Publications
Text Mined References (15)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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