Tbio CREBRF CREB3 regulatory factor

Protein Summary

Description

Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci.

Uniprot Accession IDs

• Q8IUR6
• B3DFH2
• B3KW49
• D3DQM2
• F5GXN3
• Q5HYG4
• Q5HYK0
• Q86YR3
• Q8IZG1

Gene Name

• CREBRF

Ensembl ID

• ENST00000296953
• ENSP00000296953
• ENSG00000164463
• ENST00000520420
• ENSP00000428290
• ENST00000522692
• ENSP00000431107

Symbol

• C5orf41
• LRF
• C5orf41

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.92
kinase perturbation	0.81
transcription factor binding site profile	0.77
transcription factor	0.73
tissue sample	0.7

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.01   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 26   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.01   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	CREB3 regulatory factor	VGNC:11892	462272
Macaque	CREB3 regulatory factor		703459
Mouse	CREB3 regulatory factor	MGI:1924378	77128
Rat	CREB3 regulatory factor	RGD:1310862	303016
Dog	CREB3 regulatory factor	VGNC:39603	612888

Species	Name	OMA	EggNOG	Inparanoid
Chimp	CREB3 regulatory factor
Macaque	CREB3 regulatory factor
Mouse	CREB3 regulatory factor
Rat	CREB3 regulatory factor
Dog	CREB3 regulatory factor

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q8IUR6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)

Reactome (3)

CREB3 factors activate genes (R-HSA-8874211)

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Items per page:

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1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	CREB3 factors activate genes	9 targets	R-HSA-8874211
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Unfolded Protein Response (UPR)	92 targets	R-HSA-381119

Name	Explore in Pharos	Explore in Source
CREB3 factors activate genes	9 targets	R-HSA-8874211
Metabolism of proteins	2050 targets	R-HSA-392499
Unfolded Protein Response (UPR)	92 targets	R-HSA-381119

Gene Ontology Terms (18)

Functions (3)

Components (4)

Processes (11)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
DNA-binding transcription activator activity, RNA polymerase II-specific	Inferred from Direct Assay (IDA)	NTNU_SB
RNA polymerase II regulatory region sequence-specific DNA binding	Inferred from Direct Assay (IDA)	NTNU_SB
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Model (ISM)	NTNU_SB

Protein-Protein Interactions (14)

Explore Interacting Targets

1 – 10 of 14

• See Interactions on String-DB

ATF1

Tchem

Family: TF

Novelty: 0.01450941

p_int: 0.991540207

p_ni: 0.00845898

p_wrong: 8.13e-7

Score: 0.39

Data Source: BioPlex,STRINGDB

CREB3

Tbio

Family: TF

Novelty: 0.00424318

Score: 0.97

Data Source: Reactome,STRINGDB

CREBL2

Tdark

Family: TF

Novelty: 0.19415056

Score: 0.764

Data Source: STRINGDB

ATP6V0E1

Tbio

Family: Enzyme

Novelty: 0.076209

Score: 0.729

Data Source: STRINGDB

BNIP1

Tbio

Novelty: 0.04601895

Score: 0.656

Data Source: STRINGDB

TRIB2

Tbio

Family: Kinase

Novelty: 0.02240668

Score: 0.638

Data Source: STRINGDB

CREB3L4

Tbio

Family: TF

Novelty: 0.02532901

Score: 0.571

Data Source: STRINGDB

KLHL24

Tbio

Novelty: 0.04032749

Score: 0.554

Data Source: STRINGDB

ERGIC1

Tbio

Novelty: 0.15892956

Score: 0.547

Data Source: STRINGDB

MAGEB16

Tdark

Novelty: 0.4467116

Score: 0.505

Data Source: STRINGDB

Publication Statistics

PubMed Score  27.01

PubMed score by year

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PubTator Score  201.33

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Alternative splicing
Complete proteome
Nucleus
Polymorphism
Reference proteome
Repressor
Stress response
Transcription
Transcription regulation
Transport

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
integument phenotype