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Tbio
SIAH1
E3 ubiquitin-protein ligase SIAH1

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP. Confers constitutive instability to HIPK2 through proteasomal d ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356721
  • ENSP00000349156
  • ENSG00000196470
  • ENST00000380006
  • ENSP00000369343
  • ENST00000394725
  • ENSP00000378214
  • ENST00000568007
  • ENSP00000456421

Symbol
  • HUMSIAH
  • SIAH1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
protein domain
0.92
transcription factor binding site profile
0.77
kinase perturbation
0.76
transcription factor
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.77   (req: < 5)
Gene RIFs: 74   (req: <= 3)
Antibodies: 385   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.77   (req: >= 5)
Gene RIFs: 74   (req: > 3)
Antibodies: 385   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
46.3
red blood cell density measurement
1
1
1
43.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
46.3
red blood cell density measurement
1
43.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
siah E3 ubiquitin protein ligase 1
VGNC:13770
465153
Macaque
siah E3 ubiquitin protein ligase 1
716629
Mouse
MGI:108064
20437
Rat
RGD:620449
140941
Dog
siah E3 ubiquitin protein ligase 1
VGNC:46163
100856496
Species
Name
OMA
EggNOG
Inparanoid
Chimp
siah E3 ubiquitin protein ligase 1
Macaque
siah E3 ubiquitin protein ligase 1
Mouse
Rat
Dog
siah E3 ubiquitin protein ligase 1
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8IUQ4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Amyloid fiber formation
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Axon guidance
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Axon guidance
Class I MHC mediated antigen processing & presentation
Gene Ontology Terms (28)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (351)
1 – 10 of 351
PRR20E
Tdark
p_int: 0.999999955
p_ni: 4.4e-8
p_wrong: 1e-9
Score: 0.729
Data Source: BioPlex,STRINGDB
EXOC3L2
Tbio
Novelty: 0.16366061
p_int: 0.999993038
p_ni: 0.000006962
Score: 0.416
Data Source: BioPlex,STRINGDB
JSRP1
Tdark
Novelty: 0.08386808
p_int: 0.999990203
p_ni: 0.000009762
p_wrong: 3.5e-8
Score: 0.313
Data Source: BioPlex,STRINGDB
SIAH2
Tbio
Family: Enzyme
Novelty: 0.01461174
p_int: 0.99970584
p_ni: 4.8e-8
p_wrong: 0.000294111
Score: 0.986
Data Source: BioPlex,STRINGDB
DLD
Tbio
Family: Enzyme
Novelty: 0.00214298
p_int: 0.999396481
p_ni: 0.000603519
Score: 0.59
Data Source: BioPlex,STRINGDB
SH3RF2
Tbio
Family: Enzyme
Novelty: 0.14257663
p_int: 0.999315376
p_ni: 0.000164626
p_wrong: 0.000519998
Data Source: BioPlex
AXIN1
Tbio
Novelty: 0.00175842
Score: 0.997
Data Source: STRINGDB
CACYBP
Tbio
Novelty: 0.02207811
Score: 0.989
Data Source: STRINGDB
USP19
Tbio
Family: Enzyme
Novelty: 0.04078253
Score: 0.977
Data Source: STRINGDB
UBE2N
Tbio
Novelty: 0.00620946
Score: 0.974
Data Source: STRINGDB
Publication Statistics
PubMed Score  113.77

PubMed score by year
PubTator Score  87.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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