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Tbio
CLEC10A
C-type lectin domain family 10 member A

Protein Summary
Description
Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells. This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254868
  • ENSP00000254868
  • ENSG00000132514
  • ENST00000571664
  • ENSP00000460252
  • ENST00000576617
  • ENSP00000458728

Symbol
  • CLECSF13
  • CLECSF14
  • HML
  • HML
  • MGL
  • HML2
  • CD301
  • CLECSF13
  • CLECSF14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
disease
0.61
tissue sample
0.59
phenotype
0.56
PubMedID
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.37   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 312   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.37   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 312   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (131)
FAM241A
Tdark
Novelty:  1.04041354
p_int:  0.999727063
p_ni:  0.000272935
p_wrong:  3e-9
Score:  0.513
Data Source:  BioPlex,STRINGDB
CST6
Tbio
Novelty:  0.02811473
p_int:  0.860007837
p_ni:  0.138962214
p_wrong:  0.001029948
Score:  0.187
Data Source:  BioPlex,STRINGDB
MUC1
Tchem
Novelty:  0.00024203
Score:  0.915
Data Source:  STRINGDB
MUC5AC
Tbio
Novelty:  0.00074159
Score:  0.904
Data Source:  STRINGDB
MUC4
Tbio
Novelty:  0.00193208
Score:  0.904
Data Source:  STRINGDB
MUC16
Tbio
Novelty:  0.00444587
Score:  0.902
Data Source:  STRINGDB
MUC5B
Tbio
Novelty:  0.000832
Score:  0.901
Data Source:  STRINGDB
MUC7
Tbio
Novelty:  0.00750654
Score:  0.901
Data Source:  STRINGDB
MUC13
Tbio
Novelty:  0.01282861
Score:  0.901
Data Source:  STRINGDB
MUC3A
Tbio
Novelty:  0.0576775
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
Dectin-2 family
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
Dectin-2 family
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
3
3
96.6
total cholesterol measurement
4
3
7
94.3
low density lipoprotein cholesterol measurement
6
3
9
93.6
8
8
2
1.2
93.1
apolipoprotein B measurement
2
2
3
87.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
3
96.6
total cholesterol measurement
7
94.3
low density lipoprotein cholesterol measurement
9
93.6
2
1.2
93.1
apolipoprotein B measurement
3
87.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-type lectin domain containing 10A
VGNC:9236
748824
Cow
C-type lectin domain family 10, member A
514833
Xenopus
C-type lectin domain family 10 member A
XB-GENE-947983
496661
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-type lectin domain containing 10A
Cow
C-type lectin domain family 10, member A
Xenopus
C-type lectin domain family 10 member A
Publication Statistics
PubMed Score 179.37
PubMed score by year
PubTator Score 181.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title