CLEC10A
C-type lectin domain family 10 member A
Protein Summary
Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells. This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
- ENST00000254868
- ENSP00000254868
- ENSG00000132514
- ENST00000571664
- ENSP00000460252
- ENST00000576617
- ENSP00000458728
- CLECSF13
- CLECSF14
- HML
- HML
- MGL
- HML2
- CD301
- CLECSF13
- CLECSF14
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.73 | ||
disease | 0.61 | ||
tissue sample | 0.59 | ||
phenotype | 0.56 | ||
PubMedID | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 197.5 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 312 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 197.5 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 312 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0